ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
Does preoperative neutrophil-lymphocyte ratio indicate postoperative morbidity after repair of tetralogy of Fallot?
Emrah Şişli1, Yusuf Kenan Yalçınbaş2, Yasemin Türkekul2, Adnan Yüksek3, Arda Saygılı4, C. Tayyar Sarıoğlu5
1Department of Cardiovascular Surgery, Medical Faculty of Ege University, İzmir, Turkey
2Departments of Cardiovascular Surgery, Acıbadem Bakırköy Hospital, İstanbul, Turkey
3Departments of Anesthesiology and Reanimation, Acıbadem Bakırköy Hospital, İstanbul, Turkey
4Departments of Pediatric Cardiology, Acıbadem Bakırköy Hospital, İstanbul, Turkey
5Department of Cardiovascular Surgery, Medical Faculty of Acıbadem University, İstanbul, Turkey
DOI : 10.5606/tgkdc.dergisi.2016.12043
Background: In this study, we aimed to investigate the impact of preoperative neutrophil-lymphocyte ratio on postoperative morbidity after repair of tetralogy of Fallot.

Methods: In this retrospective study, 51 patients (30 males, 21 females; median age 2 years; 1-3. quartiles 1.19 to 3.65 years) who underwent tetralogy of Fallot repair between August 2011 and October 2013 were included. The study population was divided into two groups: group 1 including patients without morbidity and group 2 including patients with morbidity.

Results: No mortality was observed in the study population. There was no significant difference in the median of preoperative neutrophil-lymphocyte ratio between the groups [0.87 (0.68-1.29) in group 1 vs. 0.75 (0.44-1.10) in group 2; p=0.094]. Vasoactive inotrope score, duration of intubation, and mediastinal drainage index were significantly higher in group 2 (p=0.014, p=0.001 and p=0.003, respectively). While preoperative and postoperative C-reactive protein were positively correlated with the corresponding neutrophil-lymphocyte ratio (p<0.01, p<0.01, respectively), preoperative neutrophil-lymphocyte ratio was not correlated with postoperative C-reactive protein (p=0.701).

Conclusion: Our study results showed that preoperative neutrophillymphocyte ratio can be a good predictor of instantaneous inflammatory status, although there is no significant relationship between preoperative neutrophil-lymphocyte ratio and morbidity after complete repair of tetralogy of Fallot.

Keywords : Cardiac surgical procedure; congenital; heart defect; inflammation; outcome assessment
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