ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
A comparison between the measurements of arterial lactate and mixed venous oxygen saturation for the evaluation of tissue perfusion after coronary artery bypass grafting
Murat Ökten1, Halim Ulugöl2, Cem Arıtürk1, Melis Tosun2, Uğur Aksu3, Hasan Karabulut1, Fevzi Toraman2
1Departments of Cardiovascular Surgery, Acıbadem University, İstanbul, Turkey
2Departments of Anaesthesiology and Reanimation, Acıbadem University, İstanbul, Turkey
3Department of Biology, İstanbul University Faculty of Science, İstanbul, Turkey
DOI : 10.5606/tgkdc.dergisi.2016.12955
Background: This study aims to analyze the possible correlation between the blood lactate levels and mixed venous oxygen saturation after coronary artery bypass grafting.

Methods: The study included a total of 147 adult patients (104 males, 43 females; mean age 59±11 years; range 36 to 87 years) who underwent elective coronary artery bypass grafting with extracorporeal circulation between November 2011 and December 2012. Arterial blood gas, mixed venous gas, and hemodynamic variables were recorded at postoperative 30, 60, 120 and 240 min, and 24 hours. The patients were classified based on the use of inotropic agents: group 1 included 53 patients who received inotropic support and group 2 included 94 patients who did not. Both groups were assessed with respect to the correlation between the arterial lactate level and mixed venous oxygen saturation, and for other hemodynamic variables.

Results: Early postoperative mortality did not occur. In group 1, a significant correlation was found between the arterial lactate level and mixed venous oxygen saturation at 240 min postoperatively. In both groups and at any time points, the levels of arterial blood gas lactate and blood glucose consistently showed a significant correlation.

Conclusion: Although blood lactate levels provide invaluable information on the adequacy of tissue perfusion, changes in lactate levels do not correlate with mixed venous oxygen saturation, addressing the need for evaluating hemodynamic changes together with lactate levels.

Keywords : Arterial lactate; mixed venous oxygen saturation; tissue perfusion
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