Histopathologic Influences of different Suture Materials on Rat Aorta

Cengiz KÖKSAL, Kürşat BOZKURT, Caner ARSLAN, Ayla Gürel SAYIN, *Şennur İLVAN, *Berk ÖZKAYNAK, *Büge ÖZ

İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, Göğüs, Kalp ve Damar Cerrahisi Anabilim Dalı, İstanbul
^*İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, Patoloji Anabilim Dalı, İstanbul

Neointimal hyperplasia is an important problem which threatens the patency at the anastomosis site in cardiovascular surgery especially in coronary artery bypass grafting and in the surgical procedures for distal arterial obstructions of the lower extremities. In our study we aimed to compare histopathologic influences of different suture materials (silk, polpropylene, polydiawanone, PTFE) in rat aorta, invivo.

In our study, 24 rats were separated into four groups, as 6 rats in each suture material group and 7/0 suture materials (silk, polypropylene, polydiaxanone, PTFE) were passed through rat aortas perpendicular, at the infrarenal site. After 14 days rats were sacrificed and aortic segment at which suture materials were passed examined under light microscope.

In silk group, inflammatory reaction, endothelial cell proliferation and myointimal proliferation were found to be significantly higher when compared to other groups. In polydiaxanone group inflammatory reaction was foud to significantly lower when compared to other groups.

Our results which reveal least inflammatory reaction with polydiaxanon is an advantage of this suture material, in mid and late term stenosis development.

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