Özet

Background: In this systematic review, we aimed to examine the risk factors and surgical outcomes of gastrointestinal complications using the meta-analysis techniques.

Methods: Studies involving patients with and without gastrointestinal complications after cardiac surgery were electronically searched using the PubMed database, Cochrane Library and Scopus database, between January 2000 and May 2022. Some studies on gastrointestinal complications examined only single gastrointestinal complication (only intestinal ischemia, only gastrointestinal bleeding or only liver failure). Studies evaluating at least three different gastrointestinal complications were included in the meta-analysis to reduce the heterogeneity. Cohort series that did not compare outcomes of patients with and without gastrointestinal complications, studies conducted in a country"s health system databases, review articles, small case series (<10 patients) were excluded from the meta-analysis.

Results: Twenty-five studies (8 prospective and 17 retrospective) with 116,105 patients were included in the meta-analysis. The pooled incidence of gastrointestinal complications was 2.51%. Patients with gastrointestinal complications were older (mean difference [MD]=4.88 [95% confidence interval [CI]: 2.85-6.92]; p<0.001) and had longer cardiopulmonary bypass times (MD=17.7 [95% CI: 4.81-30.5]; p=0.007). In-hospital mortality occurred in 423 of 1,640 (25.8%) patients with gastrointestinal complications. In-hospital mortality was 11.8 times higher in patients with gastrointestinal complications (odds ratio [OR]=11.8 [95% CI: 9.5-14.8]; p<0.001).

Conclusion: The development of gastrointestinal complications after cardiac surgery is more commonly seen in patients with comorbidities. In-hospital mortality after cardiac surgery is 11.8 times higher in patients with gastrointestinal complications than in patients without.

Gastrointestinal (GI) organs are at risk for complex and multifactorial pathologies after cardiac surgery. The severity of GI complications (GICs) after surgery varies widely. Therefore, a clear consensus on the definition of GICs after cardiac surgery has not been developed. Intestinal ischemia, GI bleeding, hyperbilirubinemia or liver failure, splenic rupture, pancreatitis, cholecystitis, intestinal perforation, pseudomembranous enterocolitis, appendicitis or diverticulitis, intestinal obstruction, and ileus are among the GICs investigated in previous studies.[1-25] It has been reported that visceral malperfusion is responsible for most GICs. Conditions such as prolonged hypotension, low cardiac output syndrome, or impaired regional blood flow cause visceral malperfusion.[26-28]

The diagnosis of GICs is often a clinical challenge. These complications may be overshadowed by sedation, severe cardiac, and pulmonary conditions. Delayed diagnosis of GICs can be often associated with catastrophic outcomes.[29-31]

In the literature, there are studies performed for isolated acute mesenteric ischemia and isolated hyperbilirubinemia after cardiac surgery.[32-34] In this systematic review, we aimed to examine the risk factors and surgical outcomes of GICs using the metaanalysis techniques.

Yöntem

Literature search strategy
Electronic searches were performed using the PubMed database (United States National Library of Medicine), the Cochrane Library, and Scopus (Elsevier), selecting a date range from January 2000 to May 2022. The meta-analysis was conducted in accordance with the Meta-analysis of Observational Studies in Epidemiology (MOOSE) criteria and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.[35,36] The terms "cardiac surgery" and "gastrointestinal complications" or "intestinal ischemia" or "mesenteric ischemia" or "gastrointestinal bleeding" or "hyperbilirubinemia" or "liver failure" or "splenic rupture" or "pancreatitis" or "cholecystitis" or "intestinal perforation" or "pseudomembranous enterocolitis" or "appendicitis" or "diverticulitis" or "intestinal obstruction" or "ileus" were used as keywords to find publications conducted in humans to have the most effective search results. In addition, the reference list of the selected articles was checked to identify potentially relevant articles. Duplicate articles were removed. All searches were screened independently by two different researchers. In case of differences between searches, another researcher was consulted for scanning security.

Study design and selection criteria
Only articles written in English were included in the meta-analysis. Studies eligible for this metaanalysis included patients who developed GICs after cardiac surgery. Some studies on GICs examined only single GIC (i.e., only intestinal ischemia or only GI bleeding or only liver failure). However, we included studies that evaluated at least three different GICs to increase similarity across GICs. Cohort series that did not compare the results of groups with or without GICs were excluded. Studies conducted in a country's health system databases were also excluded. In addition, review articles, case reports, small case series (<10 patients), Letters to the Editor, conference presentations, editorials, and how-to-do-it articles were excluded. This study is not registered in the International Prospective Register of Systematic Reviews (PROSPERO).

Data extraction
Demographic, operative, and outcome data were obtained from the main texts, tables, and figures of the relevant studies. The matched data from studies where propensity score matching was applied to preoperative variables were not included in the meta-analysis. Two independent researchers reviewed the studies and collected the data. The authors of included trials were contacted when necessary to clarify data and identify multiple publications. In the event of data inconsistency, the data were re-evaluated by another researcher and eventually a consensus was reached among the authors.

Preoperative demographic data, age, sex, atrial fibrillation (AF), hypertension (HT), diabetes mellitus (DM), chronic obstructive pulmonary disease (COPD), peripheral vascular disease (PVD), history of cerebrovascular disease (CVD), and dialysis-dependent chronic renal failure (DD-CRF) data were obtained from the relevant studies. As operative data, we collected the history of prior cardiac surgery (cardiac reoperation), emergency surgery requirement, aortic cross-clamp (ACC) time, cardiopulmonary bypass (CPB) time, and re-exploration for bleeding.

The primary outcome was defined as hospital mortality, which was defined as mortality occurring within 30 days postoperatively or without discharge. Secondary postoperative outcomes included the development of acute renal failure (ARF), new-onset AF, sepsis, peri- or postoperative myocardial infarction, postoperative stroke, and length of hospital stay.

Statistical analysis
Statistical analysis was performed using the R version 4.0.3 software (The R Foundation for Statistical Computing, Vienna, Austria). For binary variables, the odds ratio (OR) was calculated with a 95% confidence interval (CI) for proportions. A weighted mean difference was calculated with a 95% CI for means. Heterogeneity was examined using the Cochran's Q test, as well as the inconsistency index (I2) statistic. The I2 was used to measure the degree of heterogeneity: 0% to 30%, marginal heterogeneity; 30% to 50%, moderate heterogeneity; 50% to 75%, substantial heterogeneity and 75% to 100%, considerable heterogeneity. A fixed effect model was generated if I₂ was ≤30%, while a random effect model was generated if I₂ was >30%.[37,38] Forest plots were created for primary and secondary outcomes. A funnel plot was also used to examine publication bias in the primary outcome. The Harbord test was used to evaluate the evidence for asymmetry in the funnel plot.[39] A p value of <0.05 was considered statistically significant.

Bulgular

Figure 1 shows the literature selection process. A total of 1,009 articles were identified through databases and reference lists of the selected articles. After the duplicate articles were removed, the titles and abstracts of 484 articles were reviewed. After reviewing the abstracts and titles of the articles, the full texts of 88 articles thought to be relevant to the subject were evaluated. Of the 88 studies whose full texts were reviewed, 63 were excluded using the exclusion criteria. Some examples of excluded studies are studies that examined only single GIC,[40-42] series that did not compare outcomes of patients with and without GICs.[43,44] and studies conducted in a country's health system databases.[45] Finally, a total of 25 studies were used in the meta-analysis.[1-25] Due to the subject of the meta-analysis, all included articles were observational studies (8 prospective and 17 retrospective). For this meta-analysis, data were provided from a total of 116,105 patients, 2,910 of whom were diagnosed with GICs after cardiac surgery. The pooled incidence of GICs was 2.51%. Table 1 summarizes the characteristics of the included studies. The GICs investigated in the included studies are summarized in Table 2.

Figure 1. Flow chart of the study.

Table 1. Characteristics of included studies

Table 2. GICs investigated in the included studies

Table 3 shows the meta-analysis of the included studies. Patients with GICs were statistically significantly older than patients without GICs (mean difference [MD]=4.88 [95% CI: 2.85-6.92]; p<0.001; Figure 2). The GICs risk after cardiac surgery did not significantly differ by sex (OR: 0.91 [95% CI: 0.77-1.08]; p=0.291). Also, the rate of HT, DM, DD-CRF, COPD, PVD, CVD, and AF was statistically significantly higher in patients with GICs after cardiac surgery.

Table 3. Meta-analysis of preoperative, intraoperative and postoperative data of the included studies

Figure 2. Forest plot showing weight-for-age.
GIC: Gastrointestinal complications; SD: Standard deviation; MD: Mean difference; CI: Confidence interval.

The development of GICs was statistically significantly higher by 2.2 times in patients with a history of previous cardiac surgery (OR: 2.18 [95% CI: 1.42-3.36]; p<0.001). Emergency surgery increased the development of GICs (OR: 2.64 [95% CI: 1.76-3.97]; p<0.001). The CBP time was statistically significantly longer in patients with GICs (MD=17.7 [95% CI: 4.81- 30.5]; p=0.007; Figure 3). There was no statistically significant difference between the ACC times between patients with and without GICs (MD=5.92 [95% CI: -3.13-14.96]; p=0.200). Re-exploration for bleeding was statistically significantly 4.3 times higher in patients with GICs (OR: 4.30 [95% CI: 2.84-6.49]; p<0.001).

Figure 3. Forest plot for cardiopulmonary bypass time.
GIC: Gastrointestinal complications; SD: Standard deviation; MD: Mean difference; CI: Confidence interval.

Eighteen studies collected in-hospital mortality data. In-hospital mortality occurred in 423 of 1,640 (25.8%) patients with GICs. Hospital mortality was statistically significant, and it was 11.8 times higher in patients with GICs compared to patients without GICs (OR: 11.8 [95% CI: 9.5-14.8]; p<0.001; Figure 4). The Harbord test[39] did not indicate a publication bias present for in-hospital mortality (p=0.12). Funnel plots for in-hospital mortality is shown in Figure 5. Acute renal failure, new-onset AF, myocardial infarction, stroke, and sepsis were statistically significantly more frequent in patients with GICs in the postoperative period. The length of hospital stay of patients with GIC was statistically significantly longer than that of patients without GICs (MD=16.1 [95% CI: 10.6-21.6]; p<0.001).

Figure 4. Forest plots for in-hospital mortality.
GIC: Gastrointestinal complications; CI: Confidence interval.

Figure 5. Funnel plot for in-hospital mortality.

Tartışma

The two most striking results of this study are the following: (i) following cardiac surgery, 25.8% of GIC patients died in the hospital and (ii) the development of GICs after cardiac surgery increases the risk of in-hospital mortality by 11.8 times.

Gastrointestinal complications are very diverse and can threaten the patient after surgery with different symptoms. In some patients, more than one GIC may develop together, and these conditions may cause higher mortality rates than a single GIC.[46,47] The incidence of GICs after cardiac surgery varies between studies. The difference, we believe, is in how the studies describe complications. While some studies have concentrated on GICs only that may necessitate surgery, such as acute mesenteric ischemia or GI bleeding, others have broadened the definition of GICs by screening for hyperbilirubinemia, hyperamylasemia, and pseudomembranous enterocolitis. Mangi et al.[48] reported an inverse relationship between the incidence of GICs and reported mortality due to GICs. There is no controversy regarding the acceptance of mesenteric ischemia as the most fatal GIC.[3,7,8,17,19,20,29] On the contrary, discussions about the most common GICs continue for the aforementioned reasons. In recent studies by Hess et al.[5] and Haywood et al.,[23] the most common GIC was Clostridium difficile infection diagnosed by polymerase chain reaction (PCR) test. Haywood et al.[23] also diagnosed Clostridium difficile infection by PCR test. A few studies have reported that hyperbilirubinemia is the most common GICs.[1] On the other hand, overall, most studies have reported that GI bleeding is the most common GIC after cardiac surgery.[2,3,7-9,14,19,29]

In healthy individuals, the GI organs require 20% of cardiac output.[31] A significant decrease in the mesenteric blood flow is the main culprit for GICs. Peri- and postoperative hypotension, low cardiac output syndrome, high peep due to prolonged ventilation, embolization to the celiac, superior mesenteric, and inferior mesenteric arteries all reduce the splanchnic blood flow.[49,50] Splanchnic blood flow reduction not only results in mesenteric ischemia, but also causes other GICs such as GI bleeding, pancreatitis, and cholecystitis that develop with ischemic mucosal injury. In the meta-analysis, we found that peripheral artery disease was 2.4 times more frequent in patients with GICs. Extensive atherosclerosis in patients with PVD may complicate maintaining the splanchnic blood flow.

There are many pre-, intra-, and postoperative risk factors that facilitate the development of GICs in cardiac surgery. In this meta-analysis, we found that the CPB time of patients with GICs was significantly longer than that of patients without GICs. It has been reported that inflammatory mediators released due to CPB cause ischemia-reperfusion injury, increase acidosis in the gastric mucosa, and lead to impaired mucosal integrity.[51-53] Moreover, microembolism, hypothermia, and rewarming may cause deterioration in splanchnic perfusion.[1,53,54] Interestingly, studies comparing the development of GICs between off-pump and on-pump cardiac surgery have found no significant difference between the two techniques in the development of GICs.[55,56] Fiore et al.[57] showed that the splanchnic blood flow was significantly reduced, when the heart was verticalized during off-pump surgery. In the perioperative period of off-pump surgery, mesenteric hypoperfusion and the need for inotrope and vasopressor may cause GICs. On the other hand, there was no significant difference between patients with and without GICs in terms of prolonged ACC time, which has historically been associated with adverse outcomes following cardiac surgery. This result can be explained by the relatively short ACC times of the studies included in the meta-analysis.

Acute renal failure results from hypoperfusion, such as GICs after cardiac surgery. These two distinct clinical conditions with similar pathogenesis can frequently coexist. The meta-analysis showed that patients with GICs developed ARF 11.3 times more often than patients without GICs. In addition, ARF facilitates the development of GICs by decreasing the colonic transit time.[58]

This meta-analysis has some limitations. First, the heterogeneity scores in the meta-analysis are high. A possible cause of heterogeneity is the difference in design between studies. There is no clear consensus on the definition of GIS developed after cardiac surgery. Therefore, there are significant design differences between studies. Second, in this meta-analysis, it cannot be concluded that postoperative outcomes such as ARF, sepsis, and myocardial infarction are the cause or consequence of GICs. Third, all types of cardiac surgery were included in the meta-analysis, and subgroup analyses such as isolated coronary artery bypass grafting or isolated valve surgery were unable to be performed. This meta-analysis was carried out to analyze current data and draw conclusions for clinicians and future studies.

In conclusion, gastrointestinal complications usually occur in elderly patients with a higher incidence of preoperative comorbidities. Moreover, the diagnosis of gastrointestinal complications is often a clinical challenge, and symptoms may be overshadowed by sedation and severe cardiac and pulmonary conditions. Delayed diagnosis of gastrointestinal complications can be often associated with catastrophic outcomes. Acute renal failure, new-onset atrial fibrillation, myocardial infarction, strokes, and sepsis are widespread in patients with gastrointestinal complications after cardiac surgery. Based on available data, the development of gastrointestinal complications increases the hospital mortality rate by 11.8 times.

Data Sharing Statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.

Author Contributions: Idea/concept: Z.M.D.; Design: Z.M.D., M.B., M.C.K.; Control/supervision, critical review: T.A.; Data collection and/or processing: Z.M.D., B.T., M.C.K.; Analysis and/or interpretation: Z.M.D., B.T.; Literature review, references and fundings: Z.M.D., M.B., B.T., M.C.K., T.A.; Writing the article: Z.M.D., M.B.

Conflict of Interest: The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Funding: The authors received no financial support for the research and/or authorship of this article.

Kaynaklar

1) McSweeney ME, Garwood S, Levin J, Marino MR, Wang SX, Kardatzke D, et al. Adverse gastrointestinal complications after cardiopulmonary bypass: Can outcome be predicted from preoperative risk factors? Anesth Analg 2004;98:1610-7. doi: 10.1213/01. ANE.0000113556.40345.2E.

2) D'Ancona G, Baillot R, Poirier B, Dagenais F, de Ibarra JI, Bauset R, et al. Determinants of gastrointestinal complications in cardiac surgery. Tex Heart Inst J 2003;30:280-5.

3) Viana FF, Chen Y, Almeida AA, Baxter HD, Cochrane AD, Smith JA. Gastrointestinal complications after cardiac surgery: 10-year experience of a single Australian centre. ANZ J Surg 2013;83:651-6. doi: 10.1111/ans.12134.

4) Grus T, Rohn V, Brlicová L, Lindner J, Lambert L, Dane?J, et al. Gastrointestinal complications after cardiac surgery: Eight years experience in a single center. Acta Chir Belg 2014;114:332-7. doi: 10.1080/00015458.2014.11681037.

5) Hess NR, Seese LM, Hong Y, Afflu D, Wang Y, Thoma FW, et al. Gastrointestinal complications after cardiac surgery: Incidence, predictors, and impact on outcomes. J Card Surg 2021;36:894-901. doi: 10.1111/jocs.15321.

6) Golitaleb M, Golaghaie F, Mousavi MS, Harorani M, Bakhshande Abkenar H, Haghazali M, et al. Gastrointestinal complications after cardiac surgery. Iranian Heart Journal 2019;20:56-61.

7) Andersson B, Nilsson J, Brandt J, Höglund P, Andersson R. Gastrointestinal complications after cardiac surgery. Br J Surg 2005;92:326-33. doi: 10.1002/bjs.4823.

8) Bolcal C, Iyem H, Sargin M, Mataraci I, Sahin MA, Temizkan V, et al. Gastrointestinal complications after cardiopulmonary bypass: Sixteen years of experience. Can J Gastroenterol 2005;19:613-7. doi: 10.1155/2005/975612.

9) Gulkarov I, Trocciola SM, Yokoyama CC, Girardi LN, Krieger KK, Isom OW, et al. Gastrointestinal complications after mitral valve surgery. Ann Thorac Cardiovasc Surg 2014;20:292-8. doi: 10.5761/atcs.oa.13.02245.

10) Marsoner K, Voetsch A, Lierzer C, Sodeck GH, Fruhwald S, Dapunt O, et al. Gastrointestinal complications following on-pump cardiac surgery-A propensity matched analysis. PLoS One 2019;14:e0217874. doi: 10.1371/journal. pone.0217874.

11) Yoshida K, Matsumoto M, Sugita T, Nishizawa J, Matsuyama K, Tokuda Y, et al. Gastrointestinal complications in patients undergoing coronary artery bypass grafting. Ann Thorac Cardiovasc Surg 2005;11:25-8.

12) Ibrahimi A, Kuçi S, Bejko E, Llazo S, Burimi J, Bulku E. Gastrointestinal complications following cardiac surgery. AJTES 2019;3:276-82. Doi: 10.32391/ajtes.v3i1.33.

13) Vassiliou I, Papadakis E, Arkadopoulos N, Theodoraki K, Marinis A, Theodosopoulos T, et al. Gastrointestinal emergencies in cardiac surgery. A retrospective analysis of 3,724 consecutive patients from a single center. Cardiology 2008;111:94-101. doi: 10.1159/000119696.

14) Geissler HJ, Fischer UM, Grunert S, Kuhn-Régnier F, Hoelscher A, Schwinger RH, et al. Incidence and outcome of gastrointestinal complications after cardiopulmonary bypass. Interact Cardiovasc Thorac Surg 2006;5:239-42. doi:10.1510/icvts.2005.117382.

15) Filsoufi F, Rahmanian PB, Castillo JG, Scurlock C, Legnani PE, Adams DH. Predictors and outcome of gastrointestinal complications in patients undergoing cardiac surgery. Ann Surg 2007;246:323-9. doi: 10.1097/SLA.0b013e3180603010.

16) Zacharias A, Schwann TA, Parenteau GL, Riordan CJ, Durham SJ, Engoren M, et al. Predictors of gastrointestinal complications in cardiac surgery. Tex Heart Inst J 2000;27:93-9.

17) Vohra HA, Farid S, Bahrami T, Gaer JA. Predictors of survival after gastrointestinal complications in bypass grafting. Asian Cardiovasc Thorac Ann 2011;19:27-32. doi:10.1177/0218492310394803.

18) Raja SG, Haider Z, Ahmad M. Predictors of gastrointestinal complications after conventional and beating heart coronary surgery. Surgeon 2003;1:221-8. doi: 10.1016/s1479- 666x(03)80021-5.

19) Guler M, Yamak B, Erdogan M, Aydin U, Kul S, Asil R, et al. Risk factors for gastrointestinal complications in patients undergoing coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth 2011;25:637-41. doi: 10.1053/j. jvca.2010.11.013.

20) Elgharably H, Gamaleldin M, Ayyat KS, Zaki A, Hodges K, Kindzelski B, et al. Serious gastrointestinal complications after cardiac surgery and associated mortality. Ann Thorac Surg 2021;112:1266-74. doi: 10.1016/j.athoracsur.2020.09.034.

21) Byhahn C, Strouhal U, Martens S, Mierdl S, Kessler P, Westphal K. Incidence of gastrointestinal complications in cardiopulmonary bypass patients. World J Surg 2001;25:1140-4. doi: 10.1007/BF03215861.

22) Recht MH, Smith JM, Woods SE, Engel AM, Hiratzka LF. Predictors and outcomes of gastrointestinal complications in patients undergoing coronary artery bypass graft surgery: A prospective, nested case-control study. J Am Coll Surg 2004;198:742-7. doi: 10.1016/j.jamcollsurg.2004.01.007.

23) Haywood N, Mehaffey JH, Hawkins RB, Zhang A, Kron IL, Kern JA, et al. Gastrointestinal complications after cardiac surgery: Highly morbid but improving over time. J Surg Res 2020;254:306-13. doi: 10.1016/j.jss.2020.02.019.

24) Khan JH, Lambert AM, Habib JH, Broce M, Emmett MS, Davis EA. Abdominal complications after heart surgery. Ann Thorac Surg 2006;82:1796-801. doi: 10.1016/j. athoracsur.2006.05.093.

25) Aithoussa M, Atmani N, Moutakiallah Y, Abdou A, Nya F, Bamous M, et al. Gastro-intestinal complications after open heart surgery. Arch Dig Disord 2017:1;17-23. doi: 10.11604/ pamj.2016.23.265.4212

26) Allen SJ. Gastrointestinal complications and cardiac surgery. J Extra Corpor Technol 2014;46:142-9.

27) Ohri SK, Velissaris T. Gastrointestinal dysfunction following cardiac surgery. Perfusion 2006;21:215-23. doi:10.1191/0267659106pf871oa.

28) Hessel EA 2nd. Abdominal organ injury after cardiac surgery. Semin Cardiothorac Vasc Anesth 2004;8:243-63. doi: 10.1177/108925320400800306.

29) Andersson B, Andersson R, Brandt J, Höglund P, Algotsson L, Nilsson J. Gastrointestinal complications after cardiac surgery - improved risk stratification using a new scoring model. Interact Cardiovasc Thorac Surg 2010;10:366-70. doi:10.1510/icvts.2009.219113.

30) Nilsson J, Hansson E, Andersson B. Intestinal ischemia after cardiac surgery: Analysis of a large registry. J Cardiothorac Surg 2013;8:156. doi: 10.1186/1749-8090-8-156.

31) Dong G, Liu C, Xu B, Jing H, Li D, Wu H. Postoperative abdominal complications after cardiopulmonary bypass. J Cardiothorac Surg 2012;7:108. doi: 10.1186/1749-8090-7-108.

32) Deng QW, Tan WC, Zhao BC, Deng WT, Xu M, Liu WF, et al. Risk factors for postoperative acute mesenteric ischemia among adult patients undergoing cardiac surgery: A systematic review and meta-analysis. J Crit Care 2017;42:294-303. doi: 10.1016/j.jcrc.2017.08.018.

33) Raveendran D, Penny-Dimri JC, Segal R, Smith JA, Plummer M, Liu Z, et al. The prognostic significance of postoperative hyperbilirubinemia in cardiac surgery: Systematic review and meta-analysis. J Cardiothorac Surg 2022;17:129. doi:10.1186/s13019-022-01870-2.

34) Chen X, Bai M, Zhang W, Sun S, Chen X. The incidence, risk factors, and prognosis of postoperative hyperbilirubinemia after cardiac surgery: A systematic review and meta-analysis. Ann Palliat Med 2021;10:7247-57. doi: 10.21037/apm-21-410.

35) Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, et al. Meta-analysis of observational studies in epidemiology: A proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000;283:2008-12. doi: 10.1001/jama.283.15.2008.

36) Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: Elaboration and explanation. BMJ 2015;350:g7647. doi:10.1136/bmj.g7647.

37) Paul SR, Donner A. Small sample performance of tests of homogeneity of odds ratios in K 2 x 2 tables. Stat Med 1992;11:159-65. doi: 10.1002/sim.4780110203.

38) Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003;327:557-60. doi:10.1136/bmj.327.7414.557.

39) Harbord RM, Egger M, Sterne JA. A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints. Stat Med 2006;25:3443-57. doi:10.1002/sim.2380.

40) Raman JS, Kochi K, Morimatsu H, Buxton B, Bellomo R. Severe ischemic early liver injury after cardiac surgery. Ann Thorac Surg 2002;74:1601-6. doi: 10.1016/s0003- 4975(02)03877-8.

41) Fan H, Zheng Z, Feng W, Wang W, Song Y, Lin Y, et al. Risk factors and prevention of upper gastrointestinal hemorrhage after a coronary artery bypass grafting operation. Surg Today 2010;40:931-5. doi: 10.1007/s00595-009-4160-0.

42) Ghosh S, Roberts N, Firmin RK, Jameson J, Spyt TJ. Risk factors for intestinal ischaemia in cardiac surgical patients. Eur J Cardiothorac Surg 2002;21:411-6. doi: 10.1016/s1010- 7940(02)00015-5.

43) Seilitz J, Edström M, Sköldberg M, Westerling-Andersson K, Kasim A, Renberg A, et al. Early onset of postoperative gastrointestinal dysfunction is associated with unfavorable outcome in cardiac surgery: A prospective observational study. J Intensive Care Med 2021;36:1264-71. doi:10.1177/0885066620946006.

44) Sever K, Ozbek C, Goktas B, Bas S, Ugurlucan M, Mansuroglu D. Gastrointestinal complications after open heart surgery: Incidence and determinants of risk factors. Angiology 2014;65:425-9. doi: 10.1177/0003319713482357.

45) Chaudhry R, Zaki J, Wegner R, Pednekar G, Tse A, Sheinbaum R, et al. Gastrointestinal complications after cardiac surgery: A nationwide population-based analysis of morbidity and mortality predictors. J Cardiothorac Vasc Anesth 2017;31:1268-74. doi: 10.1053/j.jvca.2017.04.013.

46) Seese L, Sultan I, Gleason TG, Navid F, Wang Y, Thoma F, et al. The impact of major postoperative complications on long-term survival after cardiac surgery. Ann Thorac Surg 2020;110:128-35. doi: 10.1016/j.athoracsur.2019.09.100.

47) Crawford TC, Magruder JT, Grimm JC, Suarez-Pierre A, Sciortino CM, Mandal K, et al. Complications after cardiac operations: All are not created equal. Ann Thorac Surg 2017;103:32-40. doi: 10.1016/j.athoracsur.2016.10.022.

48) Mangi AA, Christison-Lagay ER, Torchiana DF, Warshaw AL, Berger DL. Gastrointestinal complications in patients undergoing heart operation: An analysis of 8709 consecutive cardiac surgical patients. Ann Surg 2005;241:895-901. doi:10.1097/01.sla.0000164173.05762.32.

49) Love R, Choe E, Lippton H, Flint L, Steinberg S. Positive endexpiratory pressure decreases mesenteric blood flow despite normalization of cardiac output. J Trauma 1995;39:195-9. doi: 10.1097/00005373-199508000-00003.

50) Mutlu GM, Mutlu EA, Factor P. GI complications in patients receiving mechanical ventilation. Chest 2001;119:1222-41. doi: 10.1378/chest.119.4.1222.

51) Squiccimarro E, Stasi A, Lorusso R, Paparella D. Narrative review of the systemic inflammatory reaction to cardiac surgery and cardiopulmonary bypass. Artif Organs 2022;46:568-77. doi: 10.1111/aor.14171.

52) Cremer J, Martin M, Redl H, Bahrami S, Abraham C, Graeter T, et al. Systemic inflammatory response syndrome after cardiac operations. Ann Thorac Surg 1996;61:1714-20. doi: 10.1016/0003-4975(96)00055-0.

53) Ohri SK, Becket J, Brannan J, Keogh BE, Taylor KM. Effects of cardiopulmonary bypass on gut blood flow, oxygen utilization, and intramucosal pH. Ann Thorac Surg 1994;57:1193-9. doi: 10.1016/0003-4975(94)91355-2.

54) Tofukuji M, Stahl GL, Metais C, Tomita M, Agah A, Bianchi C, et al. Mesenteric dysfunction after cardiopulmonary bypass: Role of complement C5a. Ann Thorac Surg 2000;69:799-807. doi: 10.1016/s0003-4975(99)01408-3.

55) Sanisoglu I, Guden M, Bayramoglu Z, Sagbas E, Dibekoglu C, Sanisoglu SY, et al. Does off-pump CABG reduce gastrointestinal complications? Ann Thorac Surg 2004;77:619-25. doi: 10.1016/j.athoracsur.2003.08.006.

56) Musleh GS, Patel NC, Grayson AD, Pullan DM, Keenan DJ, Fabri BM, et al. Off-pump coronary artery bypass surgery does not reduce gastrointestinal complications. Eur J Cardiothorac Surg 2003;23:170-4. doi: 10.1016/s1010- 7940(02)00762-5.

57) Fiore G, Brienza N, Cicala P, Tunzi P, Marraudino N, Schinosa Lde L, et al. Superior mesenteric artery blood flow modifications during off-pump coronary surgery. Ann Thorac Surg 2006;82:62-7. doi: 10.1016/j.athoracsur.2006.02.012.

58) Lefebvre HP, Ferré JP, Watson AD, Brown CA, Serthelon JP, Laroute V, et al. Small bowel motility and colonic transit are altered in dogs with moderate renal failure. Am J Physiol Regul Integr Comp Physiol 2001;281:R230-8. doi: 10.1152/ ajpregu.2001.281.1.R230.