Özet

Even in young non-diabetic patients with single internal mammary artery, the risk for mediastinitis still exists. Free latissimus dorsi myocutaneus flap was chosen to repair the mediastinal defect and to protect the aortic patch repair for this case with pseudoaneurysm of the aorta after coronary artery bypass. Although the early result was successful, pseudoaneurysm recurred. Lifelong antibiotic therapy could be useful in order to prevent the recurrence of this fatal complication.

Coronary artery bypass graft surgery (CABG) has became a routine in cardiac surgery since 1970. The most important contribution to the longevity of the grafts was the use of internal mammary artery (IMA). Graft patency rates for IMA were over 90% after 10 years in most of the series where patency rates of the vein grafts were almost 50% in 10 years. On the other hand routine use of internal mammary arteries increased the risk of mediastinitis in patients with certain risk factors. The risk for mediastinitis is increased significantly if bilateral IMA are used in diabetic and elderly patients, however 1% risk exists even in young non-diabetic patients with single IMA [1,2]. When post-CABG mediastinitis occurs (fever, leukocytosis, persistent purulent drainage, pain, sternal instability) it should be treated aggresively with surgical debridement and tissue flaps if needed. Longterm intavenous antibiotic therapy (6 weeks) is mandatory. If these measures are not taken properly deep sternal infection continues and secondary complications arise such as aortic pseudoaneurysm. Once it occurs it is very difficult to cure this complication. Here we present the surgical management of a patient with recurrent mediastinitis after repair of mycotic pseudoaneurysm of the ascending aorta.

The patient was a 57 years old male patient who underwent CABG 10 years ago (left IMA to left anterior descending artery). He developed staphylococcus aureus mediastinitis early after the operation and multiple surgical procedures and long course of parenteral antibiotics were used to eradicate the infectious process. However, he was left with sternal osteomyelitis and chronic cutaneus fistula from which he occasionally drained significant amount of fresh blood. He presented himself to us seeking a definitive cure for this long lasting and debilitating problem which put the patient and his family into a severe depression of the chronic disease. We started workup with a computer tomography of the chest and revealed a pseudoaneurysm of ascending aorta (6x5 cm) that eroded the upper right part of the stenum. Preoperative angiography delineated the pseudoaneurysm of the ascending aorta, significant proximal right coronary artery stenosis, patent LIMA graft and good left ventricle function (Figure 1). Echocardiography confirmed good left ventricular and valvar functions without any fistulous connection with the pseudoaneurysm cavity. Operation was done under deep hypothermia and circulatory arrest through the trap door opening of the sternum with femoral cannulation. Pseudoaneurysmal cavity was resected and the opening on the ascending aorta was closed with autologous pericardial patch. Innomimate to right coronary artery saphenous bypass was performed and sternum was closed after sternal, subcutaneous and cutaneous debridement. Early postoperative days were uneventful. He was extubated on the first postoperative day and transferred to the ward on the second postoperative day. On the 4^th postoperative day serous discharge from sternal incision appeared, and on 6th postoperative day the patient was taken to the operating room with sternal dehiscence, bilateral empyema. Extensive debridement and partial sternectomy with repair was done and intravenous vancomycin, gentamycin, closed drainage with diluted povidone iodine solution continued. Due to persistent infection and sepsis the sternum was left open and debridements were continued. There was a huge mediastinal defect. Cultures were positive for staf. aureus. After long-term open debridement, the patient was prepared for reconstructive surgery. For reconstructive surgery the left latissimus muscle was prepared as a free myocutaneous flap and anastomosed to superior tiroideal artery and external jugular vein. Remaining skin defects were closed using skin grafts taken from the left thigh (Figure 2). The patient was discharged after three months in good condition. Unfortunately one month after discharge patient came back with recurrent aortic pseudoaneurysm about 7x7 cm size (Figure 3). Patient denied reintervention and died of sepsis and mediastinal compression.

Figure 1: Preoperative aortography delineating pseudoaneurysmal pouch at the ascending aorta.

Figure 2: Sternal and mediastinal area after extensive reconstruction with free latissimus dorsi graft and skin grafts.

Figure 3: Postoperative magnetic resonance image depicting the recurrence of the aortic pseudoaneurysm three months after extensive reconsruction.

Tartışma

After open heart surgery and coronary artery bypass became routine in 1970s, mediastinitis has been observed more frequently because median sternotomy has been the standard approach and mammary artery has been used increasingly in diabetic and elderly. Still today mediastinitis after heart surgery is a rare but life threatening condition which occurs in 0.5-5% of cases. Previous sternotomy, diabetes mellitus-especially insulin dependent type, long preoperative hospital stay, complex surgery, single or bilateral IMA use, old age, long operative time, back for bleeding, long intensive care unit stay, cardiopulmonary resuscitation, obesity, obstructive lung disease have all been shown to be responsible factors. Acute complications of mediastinitis are related to massive tissue destruction of the vital organs as heart and lung, and multi-organ failure with sepsis and death. Chronic complications of mediastinitis include sternal non-union, chronic osteomyelitis with cutaneous fistula, aortic pseudoaneurysm, graft pseudoaneurysm, pulmonary artery fistula,compression to cardiac chambers and major arteries and veins [3,4]. Infectious agent is staf. aureus and staf. epidermidis which are colonized in patients skin most of the time whereas gram negative agents are occasionally seen from different sources. Whatever the causative agent is, the underlying problem is tissue trauma, hypoperfusion and metabolic derangements which is the basis for low resistance area for immune defense systems.

Current therapy is early reintervention with extensive debridement, closed drainage with diluted vancomycin or povidone iodine irrigation, sternal refixation with Robicsek technique and longterm antibiotics (4-6 weeks). Persistent mediastinitis is a life threatening condition which occurs despite medical and surgical therapy. In difficult and resistant cases reconstructive techniques as omentum, rectus, latissimus dorsi flaps with radical debridement including costochondral arches, manubrium and sternoclavicular joints is mandatory. In this case free latissimus dorsi myocutaneus flap was chosen because of a huge tissue defect and to protect the aortic patch repair [5]. Pectoral, rectus muscles and omentum were not suitable alternatives due to patients’ particular problems (atrophy, ileus, lack of IMA supply bilaterally). Although the early result was successful, pseudoaneurysm recurred and lifelong antibiotic therapy could be useful in order to prevent the recurrence of this fatal complication.

Kaynaklar

1) Milano CA, Kesler K, Archibald N, Sexton Dj, Jonas RH. Mediastinitis after coronary bypass graft surgery. Risk factors and long-term survival. Circulation 1995;92:2245-51.

2) Eckstein FS, Albes JM, Jurmann MJ. Surgical management of persistent mediastinitis after coronary bypass grafting. Ann Thorac Surg 1997;64:854-6.

3) Sabri MN, Henry D, Wechsler AS, Di Sciascio G, Vetrovec GW. Late complications involving the ascending aorta after cardiac surgery: Recognition and management. Am Heart J 1991;121:1779-83.

4) Sullivan KL, Steiner RM, Smullens SN, Griska L, Meister SG. Pseudoaneurysm of the ascending aorta after cardiac surgery. Chest 1988;93:138-43.

5) Banic A, Ris HB, Erni D. Free latissimus dorsi flap for chest wall repair after complete resection of infected sternum. Ann Thorac Surg 1995;60:1028-32.