Associations between common 3435 C>T variants of the multi-drug resistance [MDR-1 (ABCB1)] gene and abdominal aortic aneurysm: a pilot study

Şinasi Manduz,

doi:10.5606/tgkdc.dergisi.2011.008

Şinasi Manduz¹, Nurkay Katrancıoğlu¹, Oğuz Karahan¹, Mehmet Birhan Yılmaz², Öztürk Özdemir³, Öcal Berkan¹

¹Departments of Cardiovascular Surgery, Medicine Faculty of Cumhuriyet University, Sivas
²Departments of Cardiology, Medicine Faculty of Cumhuriyet University, Sivas
³Departments of Medical Genetics, Medicine Faculty of Cumhuriyet University, Sivas

DOI : 10.5606/tgkdc.dergisi.2011.008

Background: The aim of the study was to reveal the effect of the C3435T MDR-1 gene polymorphism in AAA, which has been postulated to play a role in the inflammatory process and protection against oxidative stress.

Methods: In this study, we scanned the MDR gene polymorphisms in peripheral blood samples of the 58 patients (41 males, 17 females; mean age 62.9±6.6 years) whom were operated on after the diagnosis of AAA, and of the 58 healthy individuals (38 males, 20 females; mean age 58.8±11.6 years) have normally measured aorta diameters on abdominal computed tomography scan.

Results: We found that MDR-1 C3435T gene CT variant (x²= 5.80; p=0.016) and MDR-1 C3435T gene TT variant (x²=11.47; p=0.001) polymorphisms was statistically significant in AAA cases (p<0.05). The demographic findings were similar in each group.

Conclusion: These obtained preliminary results suggest that the T allele polymorphism of the MDR-1 gene is associated with AAA. We belive that such molecular studies will blaze a trail for future studies on the understanding of AAA etiology.

Keywords : Abdominal aortic aneurysm; inflammation; MDR-1 gene polymorphism; reverse hybridization

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