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TURKISH JOURNAL OF
THORACIC AND
CARDIOVASCULAR SURGERY
Turkish Journal of Thoracic and Cardiovascular Surgery     
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  3. 10.5606/tgkdc.dergisi.2017.11929
Küçük anterior torakotomi ile perikardiyoplevral pencere açılması
Murat Biçer1, Bülent Özdemir2, İrem İris Kan1, Hüseyin Melek3, Ahmet Sami Bayram3
1Departments of Cardiovascular Surgery, Medical Faculty of Uludağ University, Bursa, Turkey
2Departments of Cardiology, Medical Faculty of Uludağ University, Bursa, Turkey
3Departments of Thoracic Surgery, Medical Faculty of Uludağ University, Bursa, Turkey
DOI : 10.5606/tgkdc.dergisi.2017.11929

Abstract

Background: This study aims to investigate the efficacy of pericardiopleural window created by small anterior thoracotomy in the treatment and diagnosis of the pericardial effusion.

Methods: Between January 2006 and January 2011, data of a total of 52 patients (27 males, 25 females; mean age 61.8 years; range 45 to 78 years) underwent pericardiopleural window due to pleural effusion were retrospectively analyzed. Pericardial effusion was diagnosed with echocardiography or computed tomography. A pericardiopleural window was created via a small anterior thoracotomy in the right or left sixth or seventh intercostal space according to the main pathology. Incisions were about 5 to 7 cm long. A 2x2 cm window in size was created from anterior surface of the pericardium to the phrenic nerve.

Results: Indications for pericardiopleural window creation were malignant effusions in 20 patients, idiopathic causes in 20 patients, infective causes in nine patients and previous cardiac surgery in three patients. The mean duration of surgery was 42.2 minutes (range, 32 to 65). No intraoperative and postoperative mortality and morbidity was seen. The mean length of hospital stay was 5.6 (range 2 to 15) days.

Conclusion: Pericardiopleural window creation with small anterior thoracotomy is an effective technique for drainage of the pericardial fluid and pericardial biopsy.

Pericardial effusion may result from the several diseases, and infections, toxic materials, and malignancy are the most common causes.[1] The fluid accumulation in the pericardial sac induces the varying degree important symptoms. The large volume of fluids prevents to the cardiac functions and leads to fatal outcomes.[1] A rapid accumulation of low amount of fluid causes cardiac tamponade, as well.[1] Recurrences are more common in pericardial effusions, and malignancies and idiopathic reasons may cause to persistent fluid accumulation in the pericardial sac.[1]

Repeated pericardiocentesis may be required and the need for more efficient and long-lasting solutions may arise. The implementation of surgical procedures which can more efficiently relieve symptoms and prevent heart failure and mortality risk due to cardiac tamponade is required. Pericardial fenestration is a surgical procedure that can sometimes be implemented as the last resort.[1] Chronic pericardial effusions resistant to medical therapy can effectively be treated by a creating of pericardiopleural window. During the procedure, effective drainage and taken of biopsy specimens can be performed as both diagnostic and therapeutic targets.[2]

In this study, we aimed to investigate the efficacy of pericardiopleural window created by small anterior thoracotomy in the diagnosis and treatment of the pericardial effusions.

Methods

A total of 52 patients’ data (27 males, 25 females; mean age 61.8 years; range 45 to 78 years) underwent pericardiopleural window operation between January 2006 and January 2014 due to chronic pericardial effusion were retrospectively evaluated. All medical reports were manually reviewed and traumatic pericardial effusions were excluded. Pericardial effusion was diagnosed with echocardiography or computed tomography (Figure 1). In all cases, a thoracotomy in the sixth or seventh intercostal space from the right or left hemithorax according to the main pathology. The incision was about 5 to 7 cm long (Figure 2). Through the intercostal space, we entered the pleural cavity over the superior margin of the rib. After placing of a retractor, we obtained samples of pleural effusion. We palpated the lung tissue and, then, we took biopsy specimens of pericardium and the lung tissue, if required. The pericardium was incised anterior to the phrenic nerve. A surgical fenestration with a window about 2x2 cm diameter was performed. A hemovac drain (Bıçakçılar, Türkiye, Bvak 400, drainage kit 12ch) was inserted into the pleural cavity.

Figure 1: A computed tomography image showing clinically evident pericardial effusion and metastasis in a patient with inoperable lung cancer. One liter of pericardial fluid was drained during the pericardiopleural window operation.

Figure 2: An image of postoperative skin incision.

Statistical analysis
The average and standard deviation of the data were calculated by using Excel program (Microsoft®, 2010, USA).

Results

Indications for pericardiopleural window creation were malignant effusion in 20 patients (38.4%), idiopathic causes in 20 patients (38.4%), infective causes in nine patients (17.4%) and previous cardiac surgery (5.8%) in three patients. The mean incision diameter was 6.3 cm (range 5 to 7 cm). Left thoracotomy was used for pericardiopleural window creation in 43 patients (82.7%). The mean duration of surgery was 42.2 (range 32 to 65) minutes. The mean length of hospital stay was 5.6 (range 2 to 15) days. No intraoperative and postoperative early stage mortality and morbidity was seen. However, the mortality rate was 23.1% and 25% at six and 12 months, respectively. The mortalities were seen in patients with malignancies. Renal and hepatic failure was seen in three patients. Infections were the cause of mortality in seven patients. One patient had intracranial hemorrhage, and one patient had gastrointestinal bleeding. Massive pulmonary embolism was the cause of death in one patient. Three patients (5.8%) were diagnosed with lymphoma. Eleven patients (21.2%) had inoperable lung cancer. Seven patients (13.5%) had tuberculosisrelated recurrent pericardial effusion requiring surgery. Two patients (3.5%) had thymic carcinoma; while another two patients (3.8%) were operated for breast cancer. Three patients (5.8%) had recurrent pericardial effusion.

Discussion

In the present study, we reported our experience with transthoracic pericardial window operation. The study results showed that pericardial window operation with a small anterior thoracotomy approach was effective with a low complication rate, compared to sternotomy or subxiphoid approach. The length of hospital stay was also short with a low rate of recurrence. Having no early stage postoperative death also suggests that pericardiopleural window creation was effective and safe way of treating pericardial effusions. The etiologies of the pericardial effusions have showed that malignant and idiopathic conditions are more often in our clinic, although some of the indications for pericardial window are; symptomatic pericardial effusions, asymptomatic effusions that warrant definitive diagnosis, coexisting pericardial, pleural or pulmonary pathology chylopericardium.[3] The main specialties which refer patients to our clinic for pericardial effusion surgery are cardiology, oncology, and endocrinology. Indeed, most idiopathic etiologies may represent undiagnosed viral infections and rheumatic diseases. Pericardiocentesis can be also used for the treatment of pericardial effusions. However, this method is associated with high recurrence rates and may not be helpful for definitive treatment.[4] Therefore, we should keep in mind that pericardial window operation cannot prevent recurrences, although it can markedly reduce the frequency.[5] Based on the literature data, recurrence rates of pericardial effusion in pericardial window operation range between 0% and %33.[6]

Although there are numerous methods for treating pericardial effusion, we used pericardial window operation to eliminate pericardial tamponade risk permanently. In addition, massive intractable pericardial effusions can be treated with pericardial window operation alone successfully.[1] It is recommended for the definitive treatment of pericardial effusion with malignant origin.[3,7] Surgical methods with minimal invasive techniques are also being more often used.[3] The most prevalent surgical approaches include subxiphoid and transthoracic approaches which are also well-tolerated by patients. In a study comparing both techniques, the authors reported that both required short operation times with similar postoperative complication rates, and length of hospital stay as well as recurrence rates were also low with both procedures.[6] Furthermore, minimally invasive surgery (video-assisted thoracoscopy), laparoscopic transabdominal pericardial window, and percutaneous balloon pericardial window are other common techniques used for surgical treatment of pericardial effusion.[7,8-10]

The main limitation of the present study is its retrospective desing. However, this rare type of surgery is uncommonly able to be performed in the prospective setting in a single-center. Therefore, large-scale studies which compare surgical tecniques in terms of pleural effusion types should be designed to establish a definite conclusion.

In conclusion, pericardiopleural window creation with small anterior thoracotomy is an effective technique for drainage of the pericardial fluid and pericardial biopsy.

Declaration of conflicting interests
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Funding
The authors received no financial support for the research and/or authorship of this article.

References

1) Kamata Y, Iwamoto M, Aoki Y, Kishaba Y, Nagashima T, Nara H, et al. Massive intractable pericardial effusion in a patient with systemic lupus erythematosus treated successfully with pericardial fenestration alone. Lupus 2008;17:1033-5.

2) Vogel B, Mall W. Thoracoscopic pericardial fenestration- -diagnostic and therapeutic aspects. Pneumologie 1990;44:184-5.

3) Komanapalli C, Sukumar M. Thoracoscopic pericardial window. Available from: http://www.ctsnet.org/sections/ clinicalresources/thoracic/expert_tech-32.html. [Accessed: May 25, 2010].

4) Laham RJ, Cohen DJ, Kuntz RE, Baim DS, Lorell BH, Simons M. Pericardial effusion in patients with cancer: outcome with contemporary management strategies. Heart 1996;75:67-71.

5) Mueller XM, Tevaearai HT, Hurni M, Ruchat P, Fischer AP, Stumpe F, et al. Long-term results of surgical subxiphoid pericardial drainage. Thorac Cardiovasc Surg 1997;45:65-9.

6) Liberman M, Labos C, Sampalis JS, Sheiner NM, Mulder DS. Ten-year surgical experience with nontraumatic pericardial effusions: a comparison between the subxyphoid and transthoracic approaches to pericardial window. Arch Surg 2005;140:191-5.

7) Toth I, Szucs G, Molnar TF. Mediastinoscope-controlled parasternal fenestration of the pericardium: definitive surgical palliation of malignant pericardial effusion. J Cardiothorac Surg 2012;7:56.

8) del Barrio LG, Morales JH, Delgado C, Benito A, Larrache J, Martinez-Cuesta A, et al. Percutaneous balloon pericardial window for patients with symptomatic pericardial effusion. Cardiovasc Intervent Radiol 2002;25:360-4.

9) Romano EJ, Glass PS. Laparoscopic pericardial window: anesthetic implications. J Cardiothorac Vasc Anesth 2002;16:623-5.

10) Mack MJ, Landreneau RJ, Hazelrigg SR, Acuff TE. Video thoracoscopic management of benign and malignant pericardial effusions. Chest 1993;103:390-393.

Keywords : Perikardiyal efüzyon; perikardioplevral pencere; torakotomi
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