Lung transplantation in children

Jonas Peter Ehrsam^1,2,3, Olga Meier Adamenko³, Manjinder Pannu⁴, Othmar Markus Schöb^1,2,3, Ilhan Inci^1,2,3,4

¹School of Medicine, University of Zurich, Zurich, Switzerland
²Department of Thoracic Surgery, Klinik Hirslanden Zurich, Zurich, Switzerland
³Klinik Hirslanden Zurich, Centre for Surgery, Zurich, Switzerland
⁴University of Nicosia Medical School, Nicosia, Cyprus

DOI : 10.5606/tgkdc.dergisi.2024.25806

Abstract

Lung transplantation is a well-established treatment for children facing advanced lung disease and pulmonary vascular disorders. However, organ shortage remains highest in children. For fitting the small chest of children, transplantation of downsized adult lungs, lobes, or even segments were successfully established. The worldwide median survival after pediatric lung transplantation is currently 5.7 years, while under consideration of age, underlying disease, and peri- and posttransplant center experience, median survival of more than 10 years is reported. Timing of referral for transplantation, ischemia-reperfusion injury, primary graft dysfunction, and acute and chronic rejection after transplantation remain the main challenges.

Abstract

Keywords : Children, lung donor, lung transplantation, pediatrics

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