ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
Surgery for ruptured sinus of Valsalva aneurysm: Five-year experience with 19 patients
Amita Yadav, Rajendra Mathur, Sanjeev Devgarha, Viju Abraham, Anula Sisodia
Sawai Man Singh Hospital, Cardiovascular and Thoracic Surgery, Jaipur, Rajasthan, India
DOI : 10.5606/tgkdc.dergisi.2014.10093

Abstract

Background: In this article, we reviewed our five-year experience in the repair of ruptured sinus of Valsalva aneurysm (RSVA), and the current literature regarding the efficacy of patch closure.

Methods: A retrospective review identified 19 patients (15 males, 4 females; mean age 28±12 years; range 14 to 55 years) who underwent RSVA repair between January 2009 and October 2013. The RSVA originated from the right coronary sinus in 17 patients (89.4%), and from the noncoronary sinus in two patients (10.5%). Ruptured sinus of Valsalva aneurysm did not originate from the left coronary sinus in any of the patients. In 11 patients (57.8%), the most common occurrence was right ventricular rupture, whereas it was right atrial rupture in eight patients (42.10%). Common associated defects were subaortic ventricular septal defect in two patients (10.7%), aortic insufficiency in seven patients (36.8%), and tricuspid insufficiency in one patient (5.2%). A bicameral approach was used for repair. Ruptured sinus of Valsalva aneurysm was repaired with an expanded polytetrafluoroethylene patch in all cases. Aortic valve was replaced in seven patients, and tricuspid in one patient.

Results: The hospital mortality rate was 5.2%. Follow-up, ranging from one month to 4.5 years, was available in 94.3% of survivors (n=18). Actual survival rate was 95%. Freedom from reoperation was 100%.

Conclusion: To conclude, surgical repair appears to be the optimal choice for the treatment of RSVA. Rapid surgical intervention after diagnosis may lead to successful outcomes.

A sinus of Valsalva aneurysm (SVA) is an infrequent occurrence, which may be either congenital or acquired, that has an incidence rate ranging from 0.14-3.5% for patients who undergo open heart surgery.[1] In addition, SVAs can rupture into any of the cardiac chambers to form an aorticocardiac fistula, but those on the right side are more affected. Moreover, males are three to four times more likely to have SVAs, and the incidence of a ruptured sinus of Valsalva aneurysm (RSVA) is higher in Asian (1.2%-4.94%) versus Western populations (0.5%-1.5%).[1] Once rupture has occurred, the mean survival period for untreated patients is one to two years, which demonstrates the need for early surgical intervention.[2]

The first successful surgical treatment for an SVA was performed in 1957 by Lillehei using a cardiopulmonary bypass (CPB).[2] He approached the aneurysm via the involved chamber, and closure was done with interrupted silk stitches. Since that time, various closure techniques (primary closure vs. patch closure) and surgical approaches (transaortic, dual, or involved chamber have been tried, but there is still no consensus on which technique is best.[3] Herein, we reviewed our five-year experience with RSVAs to assess the long-term outcome of surgical repair and the factors that influenced our patients’ prognosis.

Methods

This retrospective study was composed of 19 patients (15 males, 4 females; mean age 28±12 years; range 14 to 55 years) with an RSVA who underwent surgical repair at our facility between January 2009 and October 2013. At admission, 18 of the patients were symptomatic, and four presented with an acute onset of symptoms. Fourteen had dyspnea, 12 suffered from palpitations, 12 experienced fatigue, two had chest pain, two had a fever, and one experienced from syncope. In addition, 12 were categorized as having New York Heart Association (NYHA) functional Class III and IV (Table 1). Furthermore, a continuous “machinery” murmur was heard at the left sternal border in 17 patients. The preoperative systemic pulse pressure ranged from 40 to 150 mmHg (mean, 70±20 mmHg), and the chest radiography findings included an increased cardiothoracic ratio of 0.53±0.07 (range 0.45-0.79) with varying degrees of pulmonary plethora (Figure 1). We also found that the electrocardiographic findings were normal in just two of the patients. Ten others had left ventricular hypertrophy while one had right ventricular hypertrophy. The RSVA was diagnosed by echocardiography in 18 patients (Figure 2), and it originated from the right coronary sinus in 17 patients (89.4%) and the noncoronary sinus in two others (10.5%). None originated from the left coronary sinus. Rupture into the right ventricle was the most common finding in 11 patients (57.8%), but for eight others, it occurred in the right atrium (42.10%). Furthermore, we discovered a subaortic ventricular septal defect (VSD) in two patients (10.7%) and found that seven had aortic insufficiency (36.8%) while one had tricuspid insufficiency (5.2%) (Table 2). To repair the RSVA, we employed the bicameral approach, which includes the involved chamber and the aorta, and used expanded polytetrafluoroethylene (ePTFE) patches for all of the patients. Moreover, the aortic valve was replaced in seven of the patients and the tricuspid valve was replaced in one.

Table 1: Pre- and postoperative New York Heart Association class

Figure 1: Preoperative chest radiograph of a patient showing the increased cardiothoracic ratio and pulmonary plethora.

Figure 2: Transthoracic echocardiograph (parasternal long-axis view) showing the ruptured sinus of Valsalva opening into the right ventricle (RV) (arrow). LV: Left ventricle; Ao: Aorta; LA: Left atrium.

Table 2: Origin and site of rupture of the sinus of valsalva aneurysm

Surgical procedure
Cardiopulmonary bypass and moderate hypothermia were used in all of the cases, and direct coronary ostial antegrade hypothermic blood cardioplegia was utilized for myocardial protection. Furthermore, an oblique aortotomy was performed to check the pathology of the aneurysm, aortic cusps, and associated cardiac anomalies. For two patients with an isolated RSVA that had ruptured into the right ventricle without a VSD, an aortotomy was the preferred surgical technique, whereas the double-chamber approach was used in the remaining 17 patients with an RSVA that had ruptured into either the right atrium (n=8) or the right ventricle (n=9). This type of rupture was associated with a right (i.e., VSD) and right ventricular outflow tract obstruction (RVOTO). The RSVA was primarily repaired with a patch or aortic valve replacement (Table 3). Direct closure of the aneurysm was done in two patients (10.7%), and seven (36.84%) received a prosthetic aortic valve. Patch closure was performed on the remaining 17 patients who did not require direct closure.

The VSDs were approached through a right ventriculotomy and then closed with a patch (n=2). The surgical procedures associated with the RSVA closure are listed in Table 3.

Table 3: Coexisting lesions and corresponding procedures

Results

The early mortality rate in our study was 5.2% (n=1) as one patient dyed because of septic shock on the 12th postoperative day. Temporary atrioventricular (AV) block developed in one patient, but none of the patients required a permanent pacemaker. In addition, no ventricular arrhythmias or sudden cardiac deaths were seen in any of the patients in this series. The mean duration of the postoperative hospital stay was 10±4 days (range 4-15 days), and all 18 survivors were NYHA Class I or II when they were discharged from the hospital (Table 1). Three were classified as NYHA class II with a history of dyspnea that may have been caused by aortic valve incompetence. The other 15 had no such complaints. Finally, we determined that the actual survival rate was 94.8%, and the freedom from reoperation for reoccurrence was 100%.

Discussion

The goals of RSVA repair procedures are to close them securely, remove the aneurysmal sac, and repair any associated defects without causing heart block or aortic valve dysfunction, and different surgical strategies have evolved to achieve these goals. However, because of the rarity of RSVAs, there have been no clinical trials to show whether one surgical repair technique is superior to another.

An analysis of a published case series by Chu et al.[4] found that the incidence is approximately five times higher for patients in the Far East than for those in the West, and most studies, including ours, have found that the right coronary sinus is affected the most followed by the noncoronary sinus. The aneurysm most often ruptures into the right ventricle, with the second most common site being the right atrium. However, RSVAs have also rarely been found in the left ventricle, pulmonary artery, or interventricular septum. In our study, the aneurysm ruptured most often into the right ventricle. A ruptured left SVA is seldom seen because the left coronary cusp does not usually arise from the bulbar septum in the same manner that the right and noncoronary cusps do.

Various studies have found that males are more likely to have SVAs, with figures ranging from 51% to as high as 88%, and that patients can be diagnosed anywhere from two years old to the age of 80 (mean age 31.89 years).[3,5-23] In this study, the mean age was 30.9 years, and 78% of the patients were male.

Adams et al.[24] documented a mean survival of 3.9 years in their study comprised of patients with untreated RSVAs, which suggests that early surgical intervention is needed. Surgery is also recommended in symptomatic, nonruptured aneurysms, but optimal management for asymptomatic, nonruptured SVAs is less clear. In the report by Takach et al.,[6] a patient who refused to have surgery for an asymptomatic noncoronary SVA and trace aortic regurgitation (AR) progressed to severe AR.

A VSD is the most common cardiac anomaly found in conjunction with RSVAs, with rates of between 9 and 78% having been reported.[3,5-23] In our series, the prevalence rate for patients with a VSD was 10.5% (two out of 19), and the two with the VSD were closed with a patch. In addition, no residual VSDs were subsequently identified. Aortic valve abnormalities and incompetence are common in patients with RSVAs, and aortic valve replacement may be required at the time of RSVA closure if the cusps are highly deformed and not suitable for repair. In our series, moderate-to-severe aortic insufficiency occurred in seven patients (36.8%), and the aortic valve was replaced in all of them.

Interventional closure in the catheterization laboratory is another treatment option,[7] especially since the ideal surgical approach has yet to be determined. Controversy exists among surgical centers with regard to the best closure technique (primary closure vs. patch closure) and preferred surgical approach (dual, transaortic, and involved chamber) for RSVAs. Some reports have identified an association between the primary closure technique and recurrent rupture and worsening AR.[5,7,9,19,23] Others have recommended using a patch to close SVAs in all cases because it does not deform the aortic valve and it reduces the stress on the suture line.[7,9-13,16,23]

Jung et al.[19] noted that the transaortic repair may cause postoperative AR by progressively distorting the sinus geometry. However, Liu et al.[23] found no association between this surgical approach and AR.

The involved chamber (only) technique should only be performed on those patients without significant AR. In the dual approach, both the aorta and the involved chamber are used. Althought this type of surgery has some advantages, such as being able to repair the defect from both sides, it is more time consuming.[3,7,10,12,15,18]

When an SVA ruptures into the right ventricle without associated cardiac lesions, we perform the repair through an aortotomy with the use of a patch. If an SVA ruptures into the right atrium or right ventricle and there are associated cardiac lesions, we prefer the bicameral approach because the defect can be repaired from both sides. This approach was used in 17 of our patients (89.43%) while the transaortic approach was used in just two (10.5%). We have noticed an increasing tendency to use patch repair in recent years, and most studies have also recommended the use of the dual approach[3,7,10,12,15,18] because the operative mortality rate is generally low (0.5-11%) with this procedure and the prognosis after the surgical repair of the SVA is satisfactory.[3,5-20,23] In our series, the operative mortality rate was 5.2% and the actual survival rate was 94.7% at five years, which was similar to previously published results.[2,3,5,6]

Conclusion

Surgical repair of an RSVA is associated with an acceptably low operative risk and long-term freedom from death and reoperation. When an RSVA is diagnosed, the treatment of choice should be surgical repair as soon as possible. We recommend a case-specific surgical technique beginning with an aortotomy, and a patch should be used at the aortic end to minimize aortic leaflet distortion. The resultant defect, if opened, can be repaired either by direct suturing or patch closure, depending on the size and location.

Declaration of conflicting interests
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Funding
The authors received no financial support for the research and/or authorship of this article.

References

1) Ring WS. Congenital Heart Surgery Nomenclature and Database Project: aortic aneurysm, sinus of Valsalva aneurysm, and aortic dissection. Ann Thorac Surg 2000;69:S147-63.

2) Naka Y, Kadoba K, Ohtake S, Sawa Y, Hirata N, Nishimura M, et al. The long-term outcome of a surgical repair of sinus of valsalva aneurysm. Ann Thorac Surg 2000;70:727-9.

3) Choudhary SK, Bhan A, Sharma R, Airan B, Kumar AS, Venugopal P. Sinus of Valsalva aneurysms: 20 years' experience. J Card Surg 1997;12:300-8.

4) Chu SH, Hung CR, How SS, Chang H, Wang SS, Tsai CH, et al. Ruptured aneurysms of the sinus of Valsalva in Oriental patients. J Thorac Cardiovasc Surg 1990;99:288-98.

5) Au WK, Chiu SW, Mok CK, Lee WT, Cheung D, He GW. Repair of ruptured sinus of valsalva aneurysm: determinants of long-term survival. Ann Thorac Surg 1998;66:1604-10.

6) Takach TJ, Reul GJ, Duncan JM, Cooley DA, Livesay JJ, Ott DA, et al. Sinus of Valsalva aneurysm or fistula: management and outcome. Ann Thorac Surg 1999;68:1573-7.

7) Chen F, Li SH, Qin YW, Li P, Liu SX, Dong J, et al. Transcatheter closure of giant ruptured sinus of valsalva aneurysm. Circulation 2013;128:e1-3.

8) Lu S, Sun X, Wang C, Hong T, Xu D, Zhao W, Liu X. Surgical correction of giant extracardiac unruptured aneurysm of the right coronary sinus of Valsalva: case report and review of the literature. Gen Thorac Cardiovasc Surg 2013;61:143-6.

9) Azakie A, David TE, Peniston CM, Rao V, Williams WG. Ruptured sinus of valsalva aneurysm: early recurrence and fate f the aortic valve. Ann Thorac Surg 2000;70:1466-70.

10) Vural KM, Sener E, Taşdemir O, Bayazit K. Approach to sinus of Valsalva aneurysms: a review of 53 cases. Eur J Cardiothorac Surg 2001;20:71-6.

11) Dong C, Wu QY, Tang Y. Ruptured sinus of valsalva aneurysm: a Beijing experience. Ann Thorac Surg 2002;74:1621-4.

12) Li ZQ, Liu AJ, Li XF, Zhu YB, Liu YL. Progression of aortic regurgitation in Asian patients with congenital sinus of valsalva aneurysm. Heart Surg Forum 2013;16:E219-24.

13) Li F, Chen S, Wang J, Zhou Y. Treatment and outcome of sinus of valsalva aneurysm. Heart Lung Circ 2002;11:107-11.

14) Zhao G, Seng J, Yan B, Wei H, Qiao C, Zhao S, et al. Diagnosis and surgical treatment of ruptured aneurysm in sinus of Valsalva. Chin Med J (Engl) 2003;116:1047-50.

15) Lin CY, Hong GJ, Lee KC, Tsai YT, Tsai CS. Ruptured congenital sinus of valsalva aneurysms. J Card Surg 2004;19:99-102.

16) Harkness JR, Fitton TP, Barreiro CJ, Alejo D, Gott VL, Baumgartner WA, et al. A 32-year experience with surgical repair of sinus of valsalva aneurysms. J Card Surg 2005;20:198-204.

17) Moustafa S, Mookadam F, Cooper L, Adam G, Zehr K, Stulak J, et al. Sinus of Valsalva aneurysms--47 years of a single center experience and systematic overview of published reports. Am J Cardiol 2007;99:1159-64.

18) Wang ZJ, Zou CW, Li DC, Li HX, Wang AB, Yuan GD, et al. Surgical repair of sinus of Valsalva aneurysm in Asian patients. Ann Thorac Surg 2007;84:156-60.

19) Jung SH, Yun TJ, Im YM, Park JJ, Song H, Lee JW, et al. Ruptured sinus of Valsalva aneurysm: transaortic repair may cause sinus of Valsalva distortion and aortic regurgitation. J Thorac Cardiovasc Surg 2008;135:1153-8.

20) Yan F, Huo Q, Qiao J, Murat V, Ma SF. Surgery for sinus of valsalva aneurysm: 27-year experience with 100 patients. Asian Cardiovasc Thorac Ann 2008;16:361-5.

21) Mo A, Lin H. Surgical correction of ruptured aneurysms of the sinus of Valsalva using on-pump beating-heart technique. J Cardiothorac Surg 2010;5:37.

22) Guo HW, Sun XG, Xu JP, Xiong H, Wang XQ, Su WJ, et al. A new and simple classification for the non-coronary sinus of Valsalva aneurysm. Eur J Cardiothorac Surg 2011;40:1047-51.

23) Liu YL, Liu AJ, Ling F, Wang D, Zhu YB, Wang Q, et al. Risk factors for preoperative and postoperative progression of aortic regurgitation in congenital ruptured sinus of Valsalva aneurysm. Ann Thorac Surg 2011;91:542-8.

24) Adams JE, Sawyers JL, Scott HW Jr. Surgical treatment of aneurysms of the aortic sinuses with aorticoatrial fistula; experimental and clinical study. Surgery 1957;41:26-42.

Keywords : Acyanotic congenital heart disease; patch repair; ruptured aneurysm; sinus of Valsalva aneurysm
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