ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
Geniş proksimal aort boynunun endovasküler anevrizma tamiri sonuçlarına etkisi
Bahadır Aytekin1, Gökay Deniz1, Ferit Çetinkaya2, Serkan Mola1, Naim Boran Tümer1, Ertekin Utku Ünal3, Ahmet Barış Durukan4, Hakkı Zafer İşcan1
1Department of Cardiovascular Surgery, Ankara City Hospital, Ankara, Türkiye
2Department of Cardiovascular Surgery, Ağrı Training and Research Hospital, Ağrı, Türkiye
3Department of Cardiovascular Surgery, Ufuk University Medical Faculty, Ankara, Türkiye
4Department of Cardiovascular Surgery, Istinye University Medical Faculty, Istanbul, Türkiye
DOI : 10.5606/tgkdc.dergisi.2023.25255


Background: This study aims to investigate the effect of large proximal aortic neck diameter on post-endovascular aneurysm repair clinical outcomes.

Methods: A total of 180 patients (168 males, 12 females; mean age: 69.9±7.4 years; range, 46 to 88 years) who underwent elective endovascular aneurysm repair between June 2016 and September 2021 were retrospectively analyzed. According to the proximal infrarenal aortic neck diameter, the patients were divided into two groups: Group 1 (<25 mm; normal aortic neck) and Group 2 (≥25 mm; pre-aneurysmatic aortic neck). Patient characteristics, proximal infrarenal aortic neck diameter measurements with computed tomography angiography, and clinical outcomes were recorded. The primary endpoint was to assess post-endovascular aneurysm repair aortic neck dilatation, mortality, endoleaks, overall survival, type 1a endoleaks-free survival, and eventfree survival regarding the groups.

Results: There was no statistically significant difference in early mortality (p=0.55) and type 1a endoleak incidence between the groups (p=0.55). In Group 1, the mean change in diameter A (proximal infrarenal level) was 2.89±1.74 mm (p=0.01), and it was 2.31±2.1 mm in diameter B (proximal pre-aneurysm-sac level) (p=0.01). The mean change in Group 2 was 2.8±3.4 mm for diameter A (p<0.01) and 2.22±2.3 mm for diameter B (p<0.01). Aortic neck dilatation rates were similar between the groups (p=0.82 for diameter A; p=0.78 for diameter B). The five-year survival, event-free survival, and type 1a endoleak-free survival were also similar (p=0.54, p=0.26, p=0.24, respectively).

Conclusion: Our study results showed that patients with <25 mm and ≥25-mm aortic neck diameters had similar mid-term results and aortic neck dilatation ratio. Endovascular aneurysm repair outcomes can be improved with careful patient and graft selection, and early intervention for complications.

After the endovascular revolution, priorities for aortic aneurysm treatment have evolved. Infrarenal endovascular aortic aneurysm repair (EVAR), which offers short-term advantages over open aortic surgery, has gained popularity worldwide It is a less invasive technique with lower early morbidity and mortality besides the advantages of shorter hospital stays, more rapid rehabilitation, and more remarkable early overall survival.[1,2]

The EVAR procedures mandate adequate sealing zones for successful early and late outcomes. Therefore, the infrarenal aortic neck morphology of an aneurysm is the key point in this respect.[3] Excessive angulation of the neck, short neck length, circumferential thrombus, and reverse tapering may lead to poor proximal sealing zones causing endoleak and graft migration. However, sealing zone dilatation due to progressive aneurysmal degeneration may lead to stent graft failure, aneurysm sac dilatation, and subsequent morbidity in endovascular procedures. The proximal aortic neck dilatation has previously been investigated and shown in up to 24.6% of patients using larger diameter main body devices or excessive oversize, and the larger proximal aortic neck has been blamed in the literature for a higher risk of type 1a endoleak and worse clinical outcomes.[4,5]

In the present study, we aimed to investigate the aortic disease progression and post-EVAR anatomic changes due to endograft affecting aortic neck diameter and to evaluate the clinical outcomes after EVAR in the mid-term period.


This single-center, retrospective, case-control study was conducted at Ankara City Hospital, Department of Cardiovascular Surgery between June 2016 and September 2021. The patients who underwent elective EVAR for infrarenal abdominal aortic aneurysms (AAAs) were screened. Those with emergency and ruptured AAAs were excluded. Finally, a total of 180 patients (168 males, 12 females; mean age: 69.9±7.4 years; range, 46 to 88 years) who underwent elective EVAR, had at least one year of postoperative followup, and who had pre- and postoperative documented computed tomographic angiography (CTA) scans were included.

As CTA measurements, diameter A was defined as the diameter of the aneurysm neck at the infrarenal level, and diameter B was defined as the pre-sac diameter of the aneurysm neck (Figure 1). According to the proximal infrarenal aortic neck diameter (PIAND), the patients were divided into two groups: Group 1 (n=113) consisted of patients having normal (<25 mm) diameter A on CTA and Group 2 (n=67) consisted of patients with aneurysmatic (≥25 mm) proximal aortic neck diameter A on CTA. As a cut-off value, 25-mm PIAND was previously described as suitable for defining the border of the pre-aneurysmal neck diameter and it is currently used as a cut-off for defining large aortic neck diameter in the AAA screening programs.[6,7] Thus, we divided the patients into two groups according to this cut-off value and compared the results of patients with a normal aortic neck diameter to those with an abnormal pre-aneurysmal diameter to understand aortic disease progression.

Figure 1 (a) Preoperative measurements with assessing the CT angiography images. (b) %20 oversizing with 24 mm EVAR graft. (c) Preoperative measurements of Diameter A; (d) Preoperative measurements of Diameter B; (e) Postoperative measurements of Diameter A, (f) The enlargement of Diameter B after postoperative 6th month CT control and detected type 1a endoleak.
EVAR: Endovascular aortic repair; CT: Computed tomography.

All patients were operated by a single endovascular team in the hybrid operating room under general, local or regional anesthesia. For every patient, a standard EVAR procedure was initiated with heparin administration (5,000 IU intravenous bolus) and femoral access. Modular endografts (Medtronic EndurantTM II, Medtronic Inc., Minneapolis, MN, USA and Lifetech Ankura? TAA Stent Graft, Lifetech Scientific, Shenzen, China) were used in 174 patients and unibody endografts (Endologix AFX®, Endologix Inc., Irvine, CA, USA - Bifurcated Endograft System) were used in six patients. In all operations, 15 to 20% oversizing was applied according to the widest neck diameter (diameter A or diameter B). A completion angiogram was performed to document the status after endograft implantation. Smoking reduction, beta-blocker, antiplatelet and statin therapy were administrated in postoperative follow-up for all. During follow-up, control CTA was performed postoperatively, and the diameter exchanging, measurements were documented. Demographic data of the patients and perioperative data were obtained from the hospital database. Both groups were compared in terms of age, sex (male), diabetes mellitus, hypertension, hyperlipidemia, chronic obstructive pulmonary diseases, chronic kidney diseases, peripheric vascular diseases, coronary artery bypass graft, chronic heart failure, cerebrovascular event, cancer, smoking and history of abdominal surgery.

The primary endpoint was to investigate the changes in neck morphology after EVAR within the groups. The relationship between mid-term type 1a endoleak development and survival analysis with proximal aortic neck diameter was investigated as a secondary endpoint. Pre- and postoperative diameter A and diameter B values were measured within the groups, and statistically significant differences within and between the groups were investigated. The survival curves of the two groups were compared. The groups were examined for type 1 endoleak occurrence over the years, since aneurysm neck growth is known to be linked to it. All type 1 endoleaks were intervened. Finally, type 1 endoleak occurrence, all mortalities were admitted as an event, and the groups were compared to event-free survival curves.

Statistical analysis
Statistical analysis was performed using the SPSS version 20.0 software (IBM Corp., Armonk, NY, USA). Descriptive data were expressed in mean ± standard deviation (SD), median (min-max) or number and frequency, where applicable. The difference between the groups in terms of comorbid factors was analyzed using the chi-square and Fisher exact chi-square test. Differences in mortality and type 1a endoleak development were evaluated by chi-square and Fisher exact chi-square test. Diameter changes and the differences between the two groups were investigated with paired simple t-tests and independent sample t-test. Overall survival, type 1a endoleak-free survival, and event-free survival estimation of six years were analyzed with the logrank analysis of the Kaplan-Meier method. A p value of <0.05 was considered statistically significant with 95% confidence interval (CI).


There was no significant difference between the groups in terms of age (p=0.80), sex (p=0.12), and comorbidities (Table 1).

Table 1: Baseline characteristics of patients undergoing EVAR

The mean follow-up was 29.4±11.7 months. A total of 33 (18.3%) endoleaks were observed, 19 (16.8%) of which were in Group 1 and 14 (20.8%) of which were in Group 2. There was no significant difference between the groups regarding endoleak occurrence (p=0.55). Type 1a endoleak was seen in three patients (2.6%) in Group 1 and four (5.9%) in Group 2, and it was seen in seven (3.8%) patients in total. There was no significant difference between the groups regarding type 1a endoleak (p=0.42). All type 1a endoleaks were treated with aortic cuff extension and ballooning. No device migration was observed in any patient. A total of 33 deaths were reported, with an overall mortality rate of 18.3%. Nineteen (16.8%) of them were in Group 1, while 14 (20.8%) of them were in Group 2. In terms of mortality, there was no significant difference between the groups (p=0.55).

A mean preoperative diameter A value of 21.5±2 mm was obtained for Group 1 and 26.7±2.2 mm was obtained for Group 2. Postoperatively, the mean diameter A was 24.5±2.4 mm for Group 1 and 29.6±4.5 mm for Group 2; indicating statistically significance for both groups (p=0.001). The mean change in diameter A in Group 1 was 2.89±1.74 mm (95% CI: 2.56-3.22), and the mean change in Group 2 was 2.80±3.4 mm (95% CI: 1.97-3.63). When the changes in the two groups were compared, the small necks had slightly more enlargement, although the difference was not statistically significant (p=0.82). The mean preoperative diameter B value for Group 1 was 22.5±2.8, while it was 27.5±2.9 for Group 2. Postoperatively, the mean diameter B was 24.8±2.5 for Group 1 and 29.3±2.7 for Group 2, and it increased for each patient in both groups and increased statistically significantly (p=0.001). According to the diameter B change, the change in Group 1 was 2.31±2.1 mm (95% CI: 1.92-2.71) and the change in Group 2 was 2.22±2.3 mm (95% CI: 1.65-2.79). Although the difference between the two groups was not statistically significant (p=0.78), the diameter B in small necks was more expansive than in pre-aneurysmatic necks (Table 2). Considering the mean values, for Group 1, approximately 13.5% increase in diameter A and approximately 10.2% increase in diameter B were observed. For Group 2, an increase of approximately 10.5% was seen in diameter A and approximately 8.9% in diameter B.

Table 2: Perioperative measurements following the EVAR procedures

Overall survival estimated by Kaplan-Meier analysis was 90% at one year, 82% at three years and 79% at five years. According to groups, survival estimation was 89% at one year, 84% at three years, 81% at five years for Group 1 and 91% at one year, 79% at three years, 76% at five years for Group 2, respectively.

Freedom from type 1 endoleak was 99% at one year, 95% at three years, 95% at five years for overall: 99% at one year, 97% at three years, 97% at five years for Group 1 and 100% at one year, 92% at three years, 92% at five years for Group 2, respectively.

Freedom from event was estimated as 89% at one year, 78% at three years, 75% at five years for overall: 88% at one year, 81% at three years, 78% at five years for Group 1 and 91% at one year, 72% at three years, 69% at five years for Group 2, respectively.

Cumulative Kaplan-Meier analysis with log-rank estimated no significant difference between the two groups in terms of type 1a endoleak-free survival (p=0.24), event-free survival (p=0.26), and overall survival (p=0.54) (Figure 2).

Figure 2: (a) Cumulative Kaplan-Meier estimate for type 1a endoleaks-free survival, (b) event-free survival, and (c) overall survival in years.


During the past decade, EVAR has gained wide acceptance as the preferred treatment method for patients with suitable AAAs.[3] However, t his m ethod does not completely eliminate the risk of complications and mortality, and EVAR has its own risk of morbidity and mortality. Among the many risk factors identified for EVAR success and outcomes,[8,9] the role of PIAND has been an important focus of attention.[10-12] In the present study, the impact of preoperative PIAND on EVAR outcomes, as well as the effects of EVAR on PIAND, were examined. Our study results showed that pre-procedural normal or wide PIAND had no effect on post-EVAR complications, mortality, and survival. Significant PIAND enlargement after EVAR was observed independently of pre-EVAR PIAND values due to the oversizing issue of endovascular procedures as expected.

Identification of factors that may affect and predict post-EVAR mortality, adverse events such as leakage, graft migration, aneurysmal sack dilatation, and re-intervention may change the clinical decision regarding the choice of repair and the post-procedure surveillance management of high-risk patients. A healthy aortic sealing zone is the key factor linked to a lower incidence of these complications and higher procedural success. Large proximal aortic neck diameter is considered to be one of the factors affecting this zone.[11] Although EVAR in patients with large aneurysm necks has been associated with an increased risk of neck-related adverse events in several studies,[4,8,13] the overall understanding of EVAR outcomes in patients with large PIANDs are not adequately supported by the data. In the current study, the rates of endoleak, type 1a endoleak, and all-cause mortality rates were 16.8%, 2.7%, and 16.8%, respectively in Group 1, while these rates were 20.9%, 5.9%, and 20.9%, respectively in Group 2. No graft migration was observed in any of our patients. The cut-off value for large proximal aortic neck was accepted as ≥25 mm, as previously described in some studies.[7,14,15] However, we observed that PIAND below or above this value had no effect on neither mortality, overall endoleak, and type 1a endoleak rate (over a mean follow-up time of 29.4±11.7 months), nor six-year overall survival, type 1a endoleak-free survival, and event-free survival rates after EVAR. Aburahma et al.[12] found no correlation between the aneurysm neck diameter and type 1a endoleaks or the need for a secondary aortic cuff. Similar results were also reported by Bastos Goncalves et al.,[16] who found no increased risk of neck-related adverse events in 398 patients treated with 32- or 36-mm Endurant? stent grafts. In contrast, many other reports have associated large infrarenal neck diameter to post-EVAR adverse outcomes and/or survival. In a multi-center, retrospective study, patients with a PIAND of ≥30 mm had more type 1 endoleaks than those with value of <30 mm and large PIAND was an independent risk factor for neck-related adverse events, secondary interventions, and type 1 endoleak.[8] Howard et al.[4] reported that patients with a large proximal aortic neck had a higher rate of type 1a endoleaks and a lower five-year survival rate. In another study, Antoniou et al.[17] compiled the results of nine studies that included 7,682 patients with AAAs, grouped as patients with large versus small aortic necks. The risk of death, aneurysm-related reintervention, type 1a endoleak, sac enlargement and aneurysm rupture were significantly higher in patients with a large proximal aortic neck than those with a small neck. Also, in some other studies, worse outcomes have been reported after EVAR procedures in patients with a large proximal aortic neck.[5,9,13] The reasons for the discrepancy between the study results can be attributed to the differences in the accepted cut-off values for large PIAND, the procedures applied (e.g., oversizing percentages), endograft type, follow-up times, study population, and also, the operator. There are studies reporting that increased PIAND is not associated with increased complications after EVAR despite having a higher cut-off value for wide aneurysm,[16] compared to other studies reporting that increased PIAND is associated with increased complications after EVAR.[13,18-21] Therefore, we believe that the results obtained in our study may not be directly associated with our cut-off value. Also, the compatibility of the graft with the aorta is critical for successful fixation and the prevention of both graft migration and type 1 endoleaks. The complication and mortality rates we obtained are compatible with the literature and may even be somewhat lower.[10,20] Appropriate patient selection for EVAR is critical in this context.[21] We believe that the early detection and treatment of type 1a endoleaks could be a factor that improved our results. Therefore, we would like to emphasize the importance of close patient follow-up in the early postoperative period. However, comprehensive randomized-controlled trials seem to be necessary to definitively show the effect of pre-EVAR PIAND values on EVAR outcomes.

The success and long-term durability of EVAR depends on successful sealing between the graft and the aneurysm neck. Gradual dilatation of the aortic neck after EVAR may result in loss of the seal, endoleak, migration, and need for secondary interventions.[3,21] Neck dilatation following EVAR is a well-known occurrence, particularly in large size self-expanding endografts.[20,22] It has been shown that pathologies in the infrarenal neck or continued aneurysmal disease may lead to progressive dilatation. Moreover, it may be a result of endografts radial force.[23,24] Neck enlargement can be defined as dilatation of 3-mm or more between the first postoperative and last available CTA. The incidence of neck enlargement in all EVAR patients during two years of follow-up was 20%.[21] Therefore, it is of utmost importance to elucidate the risk factors of neck enlargement to both increase the success of the procedure and minimize complications such as endoleak and graft migration. However, the causes of neck dilatation after EVAR are still debated.[25] In this study, we also investigated whether pre-EVAR PIAND was associated with post-EVAR neck enlargement. We found that both diameter A and diameter B of the two groups increased significantly after the procedure. For Group 1, we observed approximately 13.5% increase in diameter A, while diameter B demonstrated approximately 10.2% increase. For Group 2, an increase of approximately 10.5% was seen in diameter A and approximately 8.9% in diameter B. Although there was more dilatation in patients with pre-EVAR <25-mm proximal necks, there was no significant difference between the groups in terms of increase in neither diameter. One study compared the PIAND changes after EVAR in patients with a PIAND of ?30 mm and those with a PIAND less than 30 mm. While the PIAND enlargement was 4.3 mm in the >30-mm group, this number was reported as 3 mm in the <30-mm group. However, similar to our study, this difference was not significant.[20] Other similar studies have also shown that pre-EVAR PIAND is not associated with post-EVAR proximal neck enlargement.[21-25] Diameter changes of the proximal neck after EVAR have been investigated in several studies which obtained varying results. Diehm et al.[26] reported a >15% increase in proximal neck diameter in 24.9% of patients at two-year follow-up and in 35.1% of patients at four-year follow-up. On the other hand, some researchers have argued that there is no enlargement of the aneurysm neck diameter after EVAR.[27,28]

Another issue is the clinical significance of aortic neck dilatation. This issue is still controversial,[3] as some studies have argued that proximal neck enlargement is correlated with migration and endoleak type 1, while others have claimed that there is no relationship between the two conditions.[5,21,29] The 10 to 20% oversizing regimen was suggested as a safe range in the literature[30] and, therefore, we applied a maximum of 20% oversizing in our patients. The amount of dilatation in proximal neck diameter we obtained is compatible with the literature.[20] However, with the available data, it is unclear whether enlargement is associated with pre-EVAR PIAND values, oversizing, or complications. We believe that further comprehensive studies would elucidate these relationships.

As a result, although the causes and clinical significance of proximal neck enlargement after EVAR are not fully known, pre-EVAR PIAND does not seem to be related to this enlargement. We believe that the most important reason for obtaining literature-compatible results (regarding diameter changes in PIAND) in this study is the application of appropriate oversizing.

Nonetheless, there are some limitations to this study. First, this study is limited in its generalizability due to its single-center design, which may not be representative of other populations. Second, the study is retrospective in nature, which may have introduced biases in data collection and analysis. Third, the difference in sample sizes between groups may have affected the reliability of statistical evaluations. Additionally, the mean follow-up times are relatively short, which limits the ability to make long-term interpretations. Furthermore, the difference in follow-up periods among patients is another important limitation. The decrease in elective cases during the novel coronavirus disease 2019 (COVID-19) period or the fact that patients did not come for control limited the number of patients. Therefore, the number of patients decreased at that time. Finally, the study only presents the latest values obtained, without showing the stages of dilatation in the proximal neck. This could have led to changes in enlargement between groups at later follow-ups.

In conclusion, pre-endovascular aortic repair proximal infrarenal aortic neck diameter over 25 mm within the anatomical suitability limits may not have an effect on post-endovascular aortic repair dilatation and its outcomes. Based on these findings, we suggest that endovascular aortic repair outcomes can be improved with careful patient selection, graft and oversizing selection, and early intervention for complications, and further research is needed to determine the potential impact of pre-endovascular aortic repair proximal infrarenal aortic neck diameter on endovascular aortic repair outcomes and the clinical significance of proximal neck enlargement after endovascular aortic repair.

Ethics Committee Approval: The study protocol was approved by the Ankara City Hospital Clinical Research Ethics Committee (date: 14.10.2020, no: E1-20-1217). The study was conducted in accordance with the principles of the Declaration of Helsinki.

Patient Consent for Publication: A written informed consent was obtained from each patient.

Data Sharing Statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.

Author Contributions: Idea/concept, B.A., G.D., F.C., SM, N.B.T., E.U.U., A.B.D., H.Z.I.; Design, B.A., G.D., F.C., SM, N.B.T., E.U.U., A.B.D., H.Z.I.; Control/supervision, B.A., G.D., F.C., SM, N.B.T., E.U.U., A.B.D., H.Z.I.; Data collection and/or processing, B.A., G.D., F.C., S.M., N.B.T., H.Z.I.; Analysis and/ or interpretation, B.A., G.D., F.C., SM, N.B.T., E.U.U., A.B.D., H.Z.I.; Literature review, B.A., G.D., F.C.,S.M., N.B.T.; Writing the article B.A., G.D., F.C., SM, N.B.T., E.U.U., A.B.D., H.Z.I.; Critical review, B.A., G.D., E.U.U., H.Z.I.; References and fundings, B.A., G.D., F.C.; Materials, B.A., G.D., F.C.; Other, B.A., G.D., S.M., A.B.D. All authors have read and agreed to the published version of the manuscript.

Conflict of Interest: The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Funding: The authors received no financial support for the research and/or authorship of this article.


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Keywords : Abdominal aort anevrizması, endoleak, endovasküler anevrizma tamiri
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