ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
Comparison of ADP-and collagen-induced platelet aggregation responses between patients with Buerger's disease and healthy individuals
Mine Yılmaz Demirbaş1, Muhterem Gülsever
1İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Kalp ve Damar Cerrahisi Anabilim Dalı, İstanbul
2İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Hemostaz Laboratuvarı, İstanbul
Background: We investigated platelet aggregation levels triggered by adenosine diphosphate (ADP) and collagen in patients with Buerger's disease who were not on antiplatelet or hemorheologic treatment.

Methods: We measured ADP- and collagen-induced platelet aggregation responses in 10 patients with Fontaine IIIIV Buerger's disease without a history of antiaggregant or hemorheologic therapies and in 10 male healthy individuals under the age of 50 years (control group). Measurements were made on a Chrono-log platelet aggregometer using ADP and collagen Chrono-log kits.

Results: The mean platelet aggregation responses triggered by ADP were 78.7±9.7% and 81.5±3.5% in the patient and control groups, respectively (p>0.05). Collageninduced response was 90.5±10.0% in the patient group, and %88.5±2.3% in the control group (p>0.05).

Conclusion: Our findings suggest that patients with Buerger's disease do not have a tendency to platelet aggregation.

Keywords : Adenosine diphosphate; collagen; platelet aggregation; thromboangiitis obliterans
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