Comparison of ADP-and collagen-induced platelet aggregation responses between patients with Buerger's disease and healthy individuals

Mine Yılmaz Demirbaş; Muhterem Gülsever,

Mine Yılmaz Demirbaş¹, Muhterem Gülsever

¹İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Kalp ve Damar Cerrahisi Anabilim Dalı, İstanbul
²İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Hemostaz Laboratuvarı, İstanbul

Background: We investigated platelet aggregation levels triggered by adenosine diphosphate (ADP) and collagen in patients with Buerger's disease who were not on antiplatelet or hemorheologic treatment.

Methods: We measured ADP- and collagen-induced platelet aggregation responses in 10 patients with Fontaine IIIIV Buerger's disease without a history of antiaggregant or hemorheologic therapies and in 10 male healthy individuals under the age of 50 years (control group). Measurements were made on a Chrono-log platelet aggregometer using ADP and collagen Chrono-log kits.

Results: The mean platelet aggregation responses triggered by ADP were 78.7±9.7% and 81.5±3.5% in the patient and control groups, respectively (p>0.05). Collageninduced response was 90.5±10.0% in the patient group, and %88.5±2.3% in the control group (p>0.05).

Conclusion: Our findings suggest that patients with Buerger's disease do not have a tendency to platelet aggregation.

Keywords : Adenosine diphosphate; collagen; platelet aggregation; thromboangiitis obliterans

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