ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
Use of recombinant factor VIIa as a rescue therapy for excessive bleeding after cardiac surgery
Şahin Şenay1, Hasan Karabulut1, Fevzi Toraman2, Siret Ratip3, Cem Alhan1
1Department of Cardiovascular Surgery, Medicine Faculty of Acıbadem University, İstanbul
2Department of Anesthesiology and Reanimation, Medicine Faculty of Acıbadem University, İstanbul
3Department of Hematology, Medicine Faculty of Acıbadem University, İstanbul
Excessive bleeding after cardiac surgery is associated with increased mortality and morbidity. Nonsurgical management includes regulation of activated clotting time, nonred cell (fresh frozen plasma, platelets, cryoprecipitate) blood product support, desmopressin, antifibrinolytics and activated recombinant factor VIIa. In this article, we report a 74-year-old male patient with atrial fibrillation who suffered from dyspnea for two months. There were no coagulation abnormalities preoperatively. The patient underwent aortic and mitral valve replacement with mechanical prosthesis, tricuspid valve annuloplasty and left atrial radiofrequency ablation for the treatment of atrial fibrillation. Recombinant factor VIIa was used for excessive postoperative bleeding, the bleeding decreased rapidly and ceased at the 4th hour of the medication. No postoperative thromboembolic event was detected, and no clinical problem was observed in one-year follow-up.
Keywords : Cardiac surgery; excessive bleeding; recombinant FVIIa
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