- Home
- Articles
-
Use of recombinant factor VIIa as a rescue therapy for excessive bleeding after cardiac surgery
Use of recombinant factor VIIa as a rescue therapy for excessive bleeding after cardiac surgery
Şahin Şenay1, Hasan Karabulut1, Fevzi Toraman2, Siret Ratip3, Cem Alhan1
1Department of Cardiovascular Surgery, Medicine Faculty of Acıbadem University, İstanbul
2Department of Anesthesiology and Reanimation, Medicine Faculty of Acıbadem University, İstanbul
3Department of Hematology, Medicine Faculty of Acıbadem University, İstanbul
Excessive bleeding after cardiac surgery is associated with
increased mortality and morbidity. Nonsurgical management
includes regulation of activated clotting time, nonred
cell (fresh frozen plasma, platelets, cryoprecipitate)
blood product support, desmopressin, antifibrinolytics
and activated recombinant factor VIIa. In this article,
we report a 74-year-old male patient with atrial fibrillation
who suffered from dyspnea for two months. There
were no coagulation abnormalities preoperatively. The
patient underwent aortic and mitral valve replacement with
mechanical prosthesis, tricuspid valve annuloplasty and
left atrial radiofrequency ablation for the treatment of atrial
fibrillation. Recombinant factor VIIa was used for excessive
postoperative bleeding, the bleeding decreased rapidly
and ceased at the 4th hour of the medication. No postoperative
thromboembolic event was detected, and no clinical
problem was observed in one-year follow-up.
Keywords : Cardiac surgery; excessive bleeding; recombinant FVIIa
Viewed : 9888
Downloaded : 2227