ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
Prognostic importance of plasma levels of brain natriuretic peptide in congenital cardiac surgery
Işık Şenkaya Sığnak, Murat Yanar, Hülüsi Helvacı
Uludağ Üniversitesi Tıp Fakültesi Kalp ve Damar Cerrahisi Anabilim Dalı, Bursa
DOI : 10.5606/tgkdc.dergisi.2011.078
Background: In this study we investigated the prognostic importance of the relationship of the role of pre- and postoperative N terminal-pro brain natriuretic peptide (NT-proBNP) levels in the early diagnosis and monitoring of postoperative deficiency with morbidity and mortality in patients operated on under extracorporeal circulation support for congenital cardiac surgery.

Methods: The pre- and postoperative echocardiographic data, the pre- and postoperative 2- and 24-hour NT-proBNP levels along with the hemodynamic and laboratory values of 20 consecutive patients were evaluated. Patients were divided into two groups, with those being under volume load in group 1 and those being under pressure load in group 2.

Results: The pre- and postoperative NT-proBNP levels followed a parallel course in both groups. The postoperative NT-proBNP levels were found to be higher when compared to the preoperative NT-proBNP levels in both groups. It has been observed that the NT-proBNP level gives an idea about cardiac functions when intra-group and general evaluations are considered. No significant difference could be found between the groups regarding the preoperative and postoperative NT-proBNP plasma levels.

Conclusion: In conclusion, there was no statistically significant differenece between the groups in terms of pre- and postoperative NT-proBNP levels. We advocate that the NT-proBNP levels in patients with congenital hearth disease is an important diagnostic tool in the early evaluation of pre- and poetoperative cardiac failure. In addition, it is also important test to commence proactive treatment of cardiac failure.

Keywords : Congenital cardiac surgery; heart failure; NT-proBNP
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