PROTECTION SAPHENOUS VEIN GRAFT ENDOTHELIUM WITH NITROPRUSSIDE SOLUTION

Melih Hulusi US, Alaaddin PEKEDİZ, Kaan İNAN, Kerim ÇAĞLI, Enver DURAN, Ömer Yüksel ÖZTÜRK, *Şükrü YILDIRIM, **Yılmaz CİNGÖZBOY

GATA Haydarpaşa Eğitim Hastanesi, Kalp Damar Cerrahisi Kliniği, İstanbul
* GATA Haydarpaşa Eğitim Hastanesi, Patoloji Bölümü, İstanbul
** GATA Haydarpaşa Eğitim Hastanesi, Kardiyoloji Bölümü, İstanbul

In this study we investigated to find out one of the best preparation technique by the effect of different solutions on venous morphology for harvested saphenous vein graft for CABG. Saphenous veins harvested from 10 patients were divided into three groups, and saphenous veins were divided to 3 cm segments. Group I was the control group and saphenous vein graft was enlarged by 20 mmHg, in Group II saphenous vein graft put in isotonic sodium chloride for 20 minutes and enlarged by 100 mmHg, and Group III saphenous vein graft was put in nitroprusside for 20 minutes and enlarged by 100 mmHg pressure. All saphenous vein segments were examined under light microscope for endothelial cell deprivation, intimal and medial edema and scored from 0 to 3. Mean scores were collected as datas. In nitroprusside group all scoring datas were better. As a result we found out that nitroprusside was having better protective effect on saphenous vein endothelium.

Keywords : Saphenous vein graft, endothelial injury, nitroprusside

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