ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
The effects of single and dual reservoired oxygenators on inflammatory response in cardiopulmonary bypass
Mehmet Alper Çalışal1, Onursal Buğra1, Erdal Şimşek2, Kemalettin Erdem1, Bahadır Dağlar1
1Abant İzzet Baysal Üniversitesi Tıp Fakültesi, Kalp ve Damar Cerrahisi Anabilim Dalı, Bolu, Türkiye
2Etlik İhtisas Eğitim ve Araştırma Hastanesi, Kalp ve Damar Cerrahisi Kliniği, Ankara, Türkiye
DOI : 10.5606/tgkdc.dergisi.2013.5884
Background: This study aims to investigate the effects of single and dual reservoired oxygenators used in open heart surgery using cardiopulmonary bypass (CPB) on the cytokine, complement, C-reactive protein (CRP) and white blood cells (WBC).

Methods: Patients were divided into two equal groups according to single (control group) and dual reservoired oxygenators (study group). Blood samples were collected before CPB, after heparin administration and at six and 24 hours following CPB in both groups. We analyzed the levels of complement (C3, C4), tumor necrosis factor-alpha (TNF-alpha), interleukins (IL 6-8-10), CRP, and WBC.

Results: Both groups using single and double reservoired oxygenators were similar in terms of age, sex, height, body weight, and comorbidities. There was no difference in C3, C4, TNF-alpha, IL-6, IL-8, IL-10, CRP and WBC levels, before CPB and at six and 24 hours following CPB in both groups.

Conclusion: Using single and double reservoired oxygenators during CPB in open heart surgery has no significant effect on inflammatory response.

Keywords : Cardiopulmonary bypass; complement; cytokine; oxygenator
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