ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
Investigation of the effects of leukocyte filtration in congenital heart surgery
Süleyman Sürer1, Ali Bolat2, Murat Koç3, Özlem Gülbahar4, Ali Kutsal3
Dr. Sami Ulus Obstetrics and Gynecology, Children’s Health and Diseases Training and Research Hospital, Bursa, Turkey
1Department of Cardiovascular Surgery, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
2Department of Cardiovascular Surgery, İskenderun State Hospital, Hatay, Turkey
3Department of Cardiovascular Surgery, Dr. Sami Ulus Obstetrics and Gynecology, Children’s Health and Diseases Training and Research Hospital, Ankara, Turkey
4Department of Medical Biochemistry, Medical Faculty of Gazi University, Ankara, Turkey
DOI : 10.5606/tgkdc.dergisi.2014.8609
Background: This study aims to investigate the effect of leukocyte filtration during cardiopulmonary bypass (CPB) on inflammatory reactions in congenital heart surgery.

Methods: In the study, group 1 (n=15) administered a leukocyte filter connected to arterial line after the oxygenator during CPB, while group 2 (n=15) was the control group. The patients were thoroughly assessed with respect to age, sex, congenital heart disease, total CPB duration, aortic cross-clamp duration, duration of mechanical ventilation, duration of intensive care unit (ICU) and hospital stay, total amount of chest drainage in 24 hour, inotropic drug use, total amount of transfused blood, and postoperative complications. Blood samples for elastase and complement (C5a) were obtained after induction and before sternotomy incision, prior to CPB, after protamine injection, at postoperative first hour in ICU, and at postoperative 24th hour. Blood samples for complete blood count, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine phosphokinase MB (CKMB), blood urea nitrogen (BUN) and creatinine level were taken preoperatively and at one and 24 hours postoperatively.

Results: The duration of hospital stay was longer in group 2 than group 1 (6.5±1.8 vs. 2: 9.7±5.1 days, respectively, p=0.015). C5a values increased in both groups during the third, fourth, and fifth period indicating no statistically significant differences (0.5±0.2 vs. 0.6±0.2; p=0.361 and 0.4±0.1 vs. 0.4±0.0; p=0.144 and 2.1±6.6 vs. 0.4±0.1; p=0.298, respectively). Subgroup analyses for ALT, AST, CKMB and leucocyte count revealed significant difference between the groups (p<0.05).

Conclusion: Although effects of systemic inflammation associated with CPB were statistically significantly different in both groups, no statistically significant difference was found between the group in which leucocyte filter was used to reduce these effects and the controls.

Keywords : Cardiac; cardiopulmonary bypass; inflammation; leukocyte
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