The Animal Experiments in The Research of Anticalcification of Pericardial Prosthesis

(*) Murat DİKMENGİL, Alp GÜREVİN, Nevzat DOĞAN, *Hayati EKREN, *Haydar BAĞIŞ, *Oya İNAN

Kocaeli Üniversitesi, Tıp Fakültesi Göğüs Kalp ve Damar Cerrahisi ABD,
^*TÜBİTAK Marmara Araştırma Merkezi,
TÜBİTAK Türkiye Bilimsel ve Teknik Araştırma Kurumu Marmara Araştırma Merkezi,Malzeme Araştırma Bolümü, Biomekanik Araştırma Grubu

Our goal is evaluate three different fixing solutions of the bovine pericardium used in heart valve bioprostheses. We have done pericardiectomy in four mice. We impIantet the pericardium at the near scapular area of the other four mice under intraperitonel anesthesia. On the other hand we treated three pieces of bovine pericardium with three different solutions and ve implanted these pieces at the near scapular area of three different mice. At the end of thirty days, we mea sured the calsification with atomic absorption spectrophotometer and discused our result. We measured that the glycerol of the mouse pericardium was minimal. The calcifitaion of the bovine pericardium treated with glycerol was less than those with gluteraldehyde + formalde- hyde. Pericardium treated with glycerol + formaldehyde had maximurn calcification.

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