The aim of the present study was to compare results of thrombolitic therapy with streptokinase (SK) and heparin for acute deep vein thrombosis.

The study was carried on 24 patients with acute deep venous thrombosis (ADVT) of the lower extremity. 12 patients of them with 1 week after acute symptoms were treated with streptokinase (initial: 250.000 U/30 min. iv. and 100.000 U/h. during 72 h.) and 12 of them were treated with heparin (20 U/kg/ h. iv.). All patients were performed venography before and 72 hours after treatment. All venographies were scored by Marder' s quantitative venographic scoring method and Arnesen' s qualitative lysis classification. Mean Marder's scor was 7.0±5 in SK group and was 11.8±4.4 in heparin group in femoral region (p<0.05). Total mean scor was 21.9±12 in SK group and was 31.6±10.5 in heparin group (p<0.05). The lysis of thromboembolism is higher in femoral region veins of SK group than in the other regions according to Arnesen's lysis classification (p<0.001). There was thrombolysis 75 percent of SK group and 25 persent of heparin group. There were no major bleeding and pulmonary embolism in both group.

As a result, streptokinase therapy was more effective than heparine in initial therapy of ADVT of lower extremity. In addition, the more patients are selected well, the less major bleeding and pulmonary embolism are occured.