ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
DURING CARDIOPULMONARY BYPASS DAFLON DECREASES REPERFUSION INJURY BY COMPLEMENT INHIBITION
Turhan Yavuz, *İrfan Altuntaş, Cumhur Tenekeci, *İbrahim Kılınç, **Vildan Ulusan, Ahmet Öcal, Erdoğan İbrişim, ***Ali Kutsal
Süleyman Demirel Üniversitesi Şevket Demirel Tıp Merkezi, Kalp Damar Cerrahisi Ana Bilim Dalı, Isparta
*Süleyman Demirel Üniversitesi Tıp Fakültesi, Biokimya Ana Bilim Dalı, Isparta
**Süleyman Demirel Üniversitesi Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı, Isparta
***Dr. Sami Ulus Çocuk Hastanesi, Kalp Damar Cerrahisi Ana Bilim Dalı, Ankara
Background: Daflon is basically known as a phlebotonic, vasculoprotector agent and an inhibition of complement C3 is involved in the initial part of alternative complement pathway. The inflammatory response during cardiopulmonary bypass is releated with the activation of alternative complement pathway. The aim of the present controlled-clinical study was to evaluate the potential myocardial protective effects of Daflon by measuring the serum levels of complement C3 during open heart surgery. Methods: Fifty patients selected for open heart surgery under cardiopulmonary bypass were randomly assigned to Daflon or control group. Patients were given Daflon tablet orally twice daily tablet per day or placebo 7 days preoperatively. In the Daflon group there were 25 patients (10 women and 15 men) with the mean age 59.6 ± 3.2 years. In the control group, there were 11 women and 14 men with the mean age 60.3 ± 2.9 years. Serial blood samples were collected preoperatively (venous), 20 minutes after cross-clamping (right atrium), 20 minutes after aortic unclamping (right atrium) and 24 hours postoperatively (venous). Results: Serum C3 levels in the Daflon group were significantly higher at 20 minutes after cross-clamping and 20 minutes after unclamping (p < 0.001). But, troponin I levels in the Daflon group were significantly lower than at 20 minutes after cross-clamping, 20 minutes after unclamping and 24 hours postoperatively than those of the control group (p < 0.001).

Conclusion: As a result this study confirms the cardioprotective effect of PMFF against reperfusion injury by alternative complement activation inhibition.

Keywords : Cardiopulmonary bypass, reperfusion injury
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