Methods: In this retrospective review of existing database including patients with heart disease, 1,390 consecutive cases (393 males, 997 females; mean age 58.7±10.1 years; range 23 to 87 years) who underwent isolated CABG in Shariati Hospital, Tehran Iran between August 2007 and March 2011 were recruited. Male and female sexes were compared for preoperative characteristics. A stepwise multivariate logistic regression analysis was performed to evaluate possible effects of sex on postoperative mortality and morbidity.
Results: Female patients were older with a higher prevalence of diabetes mellitus, hypertension, hypercholesterolemia and hyperlipidemia. The mortality rate was significantly higher in women compared to men (6.9% vs. 2.3%; p<0.001). Female sex was an independent predictor of postoperative mortality, septicemia, prolonged mechanical ventilation, leg infection, and renal complications.
Conclusion: Our study results show that female sex is an independent predictor of postoperative mortality and some of morbidities. Therefore, specific attention should be warranted to female patients undergoing isolated CABG.
These differences in the preoperative clinical characteristics between men and women make it hard to interpret how gender affects postoperative outcomes after CABG, and except for some recent studies,[8,10,13,14] most of the existing literature provides unadjusted outcomes with regard to this issue. In this study, we conducted multivariate logistic regression analyses using an extensive database containing more than 200 different variables to investigate the effects of sex on postoperative mortality and complications associated with CABG.
A primary outcome was defined as an early mortality rate within the first 30 postoperative days while a secondary outcome was signified by morbidities that happened during hospitalization. Additionally, patients with deep or superficial sternal, leg, or urinary tract infections, were recorded as having an infection complication, and when a pulmonary embolism, pneumonia, pleural effusion, or a pneumothorax occurred, these were categorized as having pulmonary complications. Furthermore, patients who suffered a stroke within the first 72 hours, had a transient ischemic attack (TIA), or were in a coma were classified as having neurological complications.
Statistical analysis
The results were reported as mean ± standard
deviation (SD) for quantitative variables and percentages
for categorical variables, and the two groups were
compared using Student’s t-test for continuous variables
and a Chi-square test (or Fisher’s exact test, if required)
for categorical variables. Statistical significance was
based on two-sided, design-based tests with a level of
significance set at 0.05.
The potential confounding effects of risk factors on surgical outcomes was first tested using univariate analyses for each dependent variable. When it was significant at p<0.2, the variables were entered into the stepwise multivariable logistic regression analyses, with the male gender being the reference group. All of the statistical analyses were performed using the SPSS for Windows version 16.0 software program (SPSS Inc., Chicago, IL, USA).
We also discovered that a higher proportion of the women were referred in the late stages of the Canadian Cardiovascular Society (CCS) angina classification system and the New York Heart Association (NYHA) functional classification system (class III and IV). However, there were no significant differences between the two genders regarding a family history of CAD, chronic obstructive pulmonary diseases (COPD) and cerebrovascular accidents (CVAs).
Additionally, we determined that there were no significant differences related to operative factors, including the mean perfusion time, ACCT, average number of PRBCs transfused, and mechanical ventilation, but a higher proportion of women did undergo the insertion of an IABP. However, the two groups did not differ significantly with regard to inotropic support (Table 1).
Table 1: The patients' baseline characteristics
The results of the study outcomes related to the male and female patients is shown in Table 2. The mortality rate was significantly higher in the women compared with the men (6.9% vs. 2.3%, respectively; p<0.001), and there was a significant association between female gender and postoperative mortality [odds ratio (OR)=1.58; 95% confidence interval (CI)=1.17-2.14; p<0.001].
In the unadjusted analyses, female gender generally was associated with a higher incidence of postoperative complications than the men (36.4% vs. 30.3%, respectively; OR=1.08; 95% CI=1.01-1.17; p=0.028). For instance, we detected a significant correlation between female gender and ventricular and supraventricular arrhythmia [including atrial fibrillation (AF)], prolonged mechanical ventilation, and postoperative septicemia. However, we were not able to confirm any significant relationship between female gender and vascular, renal, pulmonary, neurological, or gastrointestinal complications, leg site infections, deep sternal infections, or the need for a reoperation due to bleeding.
As shown in Table 3, in order to correct the confounding variables, the effects of gender on early surgical outcomes were measured using multivariable logistic regression analyses in the presence of other gender-specific characteristics such as, DM, HT, smoking status, opium addiction, hypertriglyceridemia, hypercholesterolemia, previous MI, and renal dysfunction as well as being over the age of 65. This revealed that female gender continued to be an independent risk factor for postoperative mortality. Furthermore, the association between female gender and postoperative septicemia along with prolonged mechanical ventilation remained significant, but we found no significant relationship between female gender and ventricular and supraventricular arrhythmia after these analyses were performed. In the unadjusted analyses, there were no significant associations between gender and renal (protective) and infection complications (including leg infection), although there was a significant correlation once we applied the logistic regression analyses.
In consistence with most recent investigations, comorbid conditions including older ages, lower creatinine clearance levels, diabetes mellitus, hypertension, hypercholesterolemia and hypertriglyceridemia were observed higher in women in our study[15-20] and a higher proportion of them referred in late stages of CCS and NYHA class III and IV.[4,21,22] More men smoked and were addicted to opium, and they also had a higher prevalence of previous MI. A number of recent studies have found that female gender is an independent risk factor for postoperative mortality,[8-10,23] but there are a few studies that do not agree with this conclusion.[24-26]
Some issues have been proposed to explain the higher postoperative mortality in female patients. As confirmed by our findings, different baseline risk factors in men and women may to some extent explain the observed differences in outcomes.[27-29] Furthermore, being diagnosed with CCS and NYHA class III and IV would increase the number of urgent surgeries, thus offering an explanation for the poorer outcomes.[21,22] Moreover, although we made an adjustment for all of the different gender-based factors via multivariate regression analyses, female gender was still significantly related to postoperative mortality.
Similar to our findings, Alam et al.,[8] in a study involving 13,115 patients who underwent isolated CABG, found that female gender was an independent risk factor for postoperative wound infection. They also determined that women had a lower risk of postoperative AF. The female patients in our study also had higher rates of AF, but the betweengender difference was not significant. Some authors believe that the observed differences in postoperative outcomes between males and females can be attributed to the varied distribution of the preoperative risk factors[5] and that some of these factors may even be more important predictors for postoperative mortality and morbidity than gender alone.[30-32]
Furthermore, in agreement with our findings, several studies have noted an increased risk for postoperative morbidities in females, including prolonged mechanical ventilation,[13,14] surgical site infection, sepsis,[14] and renal complications;[8] however, not all studies have been able to confirm this risk.[5] In addition, our data did not always correspond to that found in other studies. Hence, the existing literature seems to provide no consensus opinion regarding the relationship between morbidities and gender as they relate to the early surgical outcomes of patients who undergo isolated CABG.
The retrospective nature of our study was a limitation. In addition, our study was conducted at a tertiary care referral center, which could lead to referral bias. We also applied a stepwise multivariate logistic regression model to correct for baseline gender-specific differences, but there may have been other confounding factors that were not accounted for in this model. In addition, we excluded 330 (14.1%) of our initial sample size due to incomplete data.
Acknowledgement
The authors would like to thank the Farzan Institute
for Research and Technology for their technical
support.
Declaration of conflicting interests
The authors declared no conflicts of interest with
respect to the authorship and/or publication of this
article.
Funding
The authors received no financial support for the
research and/or authorship of this article.